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A new cytotoxic cardenolide from the latex of Antiaris toxicaria

文献类型: 外文期刊

作者: Gan, Yu Juan 1 ; Mei, Wen Li 1 ; Zhao, You Xing 2 ; Dai, Hao Fu 1 ;

作者机构: 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

关键词: Antiaris toxicaria;Moraceae;Toxicarioside E;Cardenolide;Cytotoxicity

期刊名称:CHINESE CHEMICAL LETTERS ( 影响因子:6.779; 五年影响因子:4.558 )

ISSN: 1001-8417

年卷期: 2009 年 20 卷 4 期

页码:

收录情况: SCI

摘要: A new cardenolide, toxicarioside E (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceac). Its structure was elucidated on the basis of spectral data and chemical evidence. Compound 1 showed significant cytotoxicity against K562 and SGC-7901 cell lines in vitro by MTT method with the IC(50) value of 0.026 and 0.027 mu g/mL, respectively. (C) 2008 Hao Fu Dai. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

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