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Actinomycetes for Marine Drug Discovery Isolated from Mangrove Soils and Plants in China

文献类型： 外文期刊

作者： Hong, Kui 1 ; Gao, An-Hui 2 ; Xie, Qing-Yi 1 ; Gao, Hao 3 ; Zhuang, Ling 1 ; Lin, Hai-Peng 1 ; Yu, Hai-Ping 2 ; Li, Jia 2 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

2.Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China

3.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China

4.Newcastle Univ, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

5.Chinese Acad Sci, Inst Microbiol, Beijing 100081,

关键词： Mangroves;actinomycete diversity;marine drug discovery;high-throughput screening;growth inhibition;protein tyrosine phosphatase 1B;aurora kinase A;caspase 3

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

ISSN： 1660-3397

年卷期： 2009 年 7 卷 1 期

页码：

收录情况： SCI

摘要： The mangrove ecosystem is a largely unexplored source for actinomycetes with the potential to produce biologically active secondary metabolites. Consequently, we set out to isolate, characterize and screen actinomycetes from soil and plant material collected from eight mangrove sites in China. Over 2,000 actinomycetes were isolated and of these approximately 20%, 5%, and 10% inhibited the growth of Human Colon Tumor 116 cells, Candida albicans and Staphylococcus aureus, respectively, while 3% inhibited protein tyrosine phosphatase 1B (PTP1B), a protein related to diabetes. In addition, nine isolates inhibited aurora kinase A, an anti-cancer related protein, and three inhibited caspase 3, a protein related to neurodegenerative diseases. Representative bioactive isolates were characterized using genotypic and phenotypic procedures and classified to thirteen genera, notably to the genera Micromonospora and Streptomyces. Actinomycetes showing cytotoxic activity were assigned to seven genera whereas only Micromonospora and Streptomyces strains showed anti-PTP1B activity. We conclude that actinomycetes isolated from mangrove habitats are a potentially rich source for the discovery of anti-infection and anti-tumor compounds, and of agents for treating neurodegenerative diseases and diabetes.

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