文献类型： 外文期刊
作者： Yang, Li 1 ; Dong, Guan-Hai 1 ; Ma, Qing-Yun 1 ; Xie, Qing-Yi 1 ; Guo, Jiao-Cen 1 ; Lu, Jia-Ju 4 ; Wu, You-Gen 3 ; Dai, Hao-Fu 1 ; Zhao, You-Xing 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Res & Dev Nat Prod Li Folk Med Hainan Prov, Haikou 571101, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Natl Key Lab Trop Crop Breeding, Haikou 571101, Peoples R China
3.Hainan Univ, Sanya Nanfan Res Inst, Sanya 572025, Peoples R China
4.Guizhou Inst Subtrop Crops, Xingyi 562400, Guizhou, Peoples R China
关键词： Ganoderma amboinense . lanostane triterpenoid; alpha-glucosidase inhibitory activity; Anti-inflammatory activity
期刊名称：PHYTOCHEMISTRY （ 影响因子：3.8； 五年影响因子：4.0 ）
ISSN： 0031-9422
年卷期： 2024 年 218 卷
页码：
收录情况： SCI
摘要： Lanostane-type triterpenoids are the main characteristic constituents in Ganoderma mushrooms. Phytochemical analysis on the ethanol extract of the fruiting bodies of Ganoderma amboinense led to isolation and identification of twelve previously undescribed lanostane triterpenoids (1-12). Their chemical structures were determined by HR-ESI-MS, IR, and NMR spectroscopic analysis, NMR calculation, as well as X-ray crystallography. All isolates were evaluated for the alpha-glucosidase inhibitory and anti-inflammatory activities. Compounds 1, 5, 6, and 11 showed significant alpha-glucosidase inhibitory activity with IC50 values ranging from 33.5 mu M to 96.0 mu M. Moreover, compound 12 showed anti-inflammatory activity with IC50 value of 21.7 +/- 2.1 mu M.
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