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Cytotoxic prenylated xanthones from Calophyllum inophyllum

文献类型： 外文期刊

作者： Xiao, Qi 1 ; Zeng, Yan-Bo 1 ; Mei, Wen-Li 1 ; Zhao, You-Xing 2 ; Deng, Yuan-Yuan 1 ; Dai, Hao-Fu 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China

关键词： Calophyllum inophyllum;cytotoxic activity;prenylated xanthone;caloxanthone N

期刊名称：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH （ 影响因子：1.569； 五年影响因子：1.598 ）

ISSN： 1028-6020

年卷期： 2008 年 10 卷 10 期

页码：

收录情况： SCI

摘要： A new prenylated xanthone (1), named caloxanthone N, together with two known constituents, gerontoxanthone C (2) and 2-hydroxyxanthone (3), was isolated from the ethanolic extract of the twigs of Calophyllum inophyllum. Their structures were completely elucidated using a combination of 1D, 2D NMR techniques (COSY, HMQC, HMBC, and ROESY) and HR-ESI-MS analyses. Compounds 1 and 2 exhibited cytotoxicity against chronic myelogenous leukemia cell line (K562) with IC50 values of 7.2 and 6.3gml-1, respectively.

  • 相关文献

[1]Caloxanthones O and P: Two New Prenylated Xanthones from Calophyllum inophyllum. Dai, Hao-Fu,Zeng, Yan-Bo,Xiao, Qi,Han, Zhuang,Mei, Wen-Li,Dai, Hao-Fu,Zeng, Yan-Bo,Mei, Wen-Li,Zhao, You-Xing. 2010

[2]A new prenylated xanthone from the branches of Calophyllum inophyllum. Wei, Dai-Jing,Mei, Wen-Li,Zeng, Yan-Bo,Wu, Xu-Dong,Dai, Hao-Fu,Wei, Dai-Jing,Zhong, Hui-Ming. 2011

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