Polymorphic Study of FecX(G), FecG(H) and Fec(B) Mutations in Four Domestic Sheep Breeds in the Lower Yellow River Valley of China

文献类型： 外文期刊

第一作者： Zhang, Chuan-Sheng

作者： Zhang, Chuan-Sheng;Geng, Li-Ying;Du, Li-Xin

作者机构：

关键词： FecX(G);FecG(H);Fec(B);sheep;mutation;prolificacy;China

期刊名称：JOURNAL OF ANIMAL AND VETERINARY ADVANCES （ 影响因子：0.365； 五年影响因子：0.359 ）

ISSN： 1680-5593

年卷期： 2011 年 10 卷 17 期

页码：

收录情况： SCI

摘要： Genetic mutations with major effects on ovulation rate in sheep were recently identified in two genes of the Transforming Growth Factor (TGF(beta)) superfamily and a TGF(beta) receptor, namely BMP15, GDF9 and BMPRIB. The FecX(G), FecG(H) and Fec(B) were performed to screen four sheep breeds (small tailed Han, Wadi, big tailed Han and Shandi sheep) distributed along the lower Yellow river valley of China by forced PCR-RFLP method if these genes are responsible for their high prolificacies. The Fec(B) mutation was found in small tailed Han and Wadi sheep but absent in big tailed Han and Shandi sheep. The 154 small tailed Han sheep included all three genotypes (Fec(B)/Fec(B), Fec(B)/Fec(+) and Fec(+)/Fec(+)) at frequencies of 0.54, 0.40 and 0.06, respectively whereas the samples of 30 Wadi sheep were only detected two genotypes, 4 were heterozygous Fec(B)/Fec(+) and 26 Fec(+)/Fec(+). The frequency of the Fec(B) allele in small tailed Han and Wadi sheep were 0.74 and 0.07, respectively. Results indicated that the Fec(B) mutation is not fixed in two sheep population. The same FecX(G) mutation of the BMP-15 gene was only found in small tailed Han ewes as in Belclare and Cambridge ewes, frequencies of genotypes FecX(G+), FecX(++) and FecX(GG) were 0.70, 0.27 and 0.03, respectively. There was no evidence of FecG(H) in any of the breeds sampled. The discovery of the Fec(B) mutation in small tailed Han sheep and Wadi sheep will facilitate the use of Fec(B) allele in improving the prolificacy of non-prolific sheep breeds of China.

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