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Three new furanones from endophytic fungus Hypoxylon vinosopulvinatum DYR-1-7 from Cinnamomum cassia with their antifungal activity

文献类型: 外文期刊

作者: Lv, Jia 1 ; Zhou, Hong 4 ; Dong, Limei 6 ; Wang, Hao 7 ; Yang, Li 7 ; Yu, Haiqian 8 ; Wu, Peixi 9 ; Zhou, Le 10 ; Yang, Quan 1 ; Liang, Yongqian 9 ; Luo, Bi 1 ;

作者机构: 1.Guangdong Pharmaceut Univ, Sch Chinese Mat Med, Guangzhou, Guangdong, Peoples R China

2.Key Lab State Adm Tradit Chinese Med Prod & Dev Ca, Guangzhou, Guangdong, Peoples R China

3.Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China

4.Nanfang Hosp, Natl Clin Res Ctr Kidney Dis, Guangzhou, Guangdong, Peoples R China

5.Guangdong Prov Clin Res Ctr Kidney Dis, Guangzhou, Guangdong, Peoples R China

6.Guangdong Ecoengn Polytech, Guangzhou, Guangdong, Peoples R China

7.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou, Hainan, Peoples R China

8.Lei Yun Shang Pharmaceut Grp Co Ltd, Suzhou, Jiangsu, Peoples R China

9.Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou, Guangdong, Peoples R China

10.South China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China

关键词: Cinnamomum cassia; endophytic fungus; secondary metabolites; Hypoxylon vinosopulvinatum; antifungal activity

期刊名称:NATURAL PRODUCT RESEARCH ( 影响因子:2.2; 五年影响因子:2.3 )

ISSN: 1478-6419

年卷期: 2023 年

页码:

收录情况: SCI

摘要: Hypoxylon vinosopulvinatum DYR-1-7 is a endophytic fungus isolated from the Cinnamomum cassia Presl and has an inhibitory effect on Lasiodiplodia pseudotheobromae. Three new furanones, hypoxylonone A-C (1-3), as well as three known compounds (4-6), were isolated from an EtOAc extract of H. vinosopulvinatum DYR-1-7. The structures were determined by spectroscopic data analysis using UV, IR, 1D-, 2D-NMR and HR-ESI-MS. The absolute configurations of 1- 3 were elucidated by electronic circular dichroism (ECD) analyses. In the antifungal bioassay, Hypoxylonone B and C exhibited strong inhibitory effects on L. pseudotheobromae with IC50 value at the concentration of 1.01 and 2.40 mu g/mL, respectively. Compound 6 showed medium antifungal activity with IC50 value at the concentration of 10.67 mu g/mL on Fusarium oxysporum. Compounds 3 and 4 displayed medium antifungul effects on Candida albicans.

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