Three new furanones from endophytic fungus Hypoxylon vinosopulvinatum DYR-1-7 from Cinnamomum cassia with their antifungal activity
文献类型： 外文期刊
作者： Lv, Jia 1 ; Zhou, Hong 4 ; Dong, Limei 6 ; Wang, Hao 7 ; Yang, Li 7 ; Yu, Haiqian 8 ; Wu, Peixi 9 ; Zhou, Le 10 ; Yang, Quan 1 ; Liang, Yongqian 9 ; Luo, Bi 1 ;
作者机构： 1.Guangdong Pharmaceut Univ, Sch Chinese Mat Med, Guangzhou, Guangdong, Peoples R China
2.Key Lab State Adm Tradit Chinese Med Prod & Dev Ca, Guangzhou, Guangdong, Peoples R China
3.Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China
4.Nanfang Hosp, Natl Clin Res Ctr Kidney Dis, Guangzhou, Guangdong, Peoples R China
5.Guangdong Prov Clin Res Ctr Kidney Dis, Guangzhou, Guangdong, Peoples R China
6.Guangdong Ecoengn Polytech, Guangzhou, Guangdong, Peoples R China
7.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou, Hainan, Peoples R China
8.Lei Yun Shang Pharmaceut Grp Co Ltd, Suzhou, Jiangsu, Peoples R China
9.Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou, Guangdong, Peoples R China
10.South China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China
关键词： Cinnamomum cassia; endophytic fungus; secondary metabolites; Hypoxylon vinosopulvinatum; antifungal activity
期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.2； 五年影响因子：2.3 ）
ISSN： 1478-6419
年卷期： 2023 年
页码：
收录情况： SCI
摘要： Hypoxylon vinosopulvinatum DYR-1-7 is a endophytic fungus isolated from the Cinnamomum cassia Presl and has an inhibitory effect on Lasiodiplodia pseudotheobromae. Three new furanones, hypoxylonone A-C (1-3), as well as three known compounds (4-6), were isolated from an EtOAc extract of H. vinosopulvinatum DYR-1-7. The structures were determined by spectroscopic data analysis using UV, IR, 1D-, 2D-NMR and HR-ESI-MS. The absolute configurations of 1- 3 were elucidated by electronic circular dichroism (ECD) analyses. In the antifungal bioassay, Hypoxylonone B and C exhibited strong inhibitory effects on L. pseudotheobromae with IC50 value at the concentration of 1.01 and 2.40 mu g/mL, respectively. Compound 6 showed medium antifungal activity with IC50 value at the concentration of 10.67 mu g/mL on Fusarium oxysporum. Compounds 3 and 4 displayed medium antifungul effects on Candida albicans.
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