Phenethoxy Derivatives with Anti-inflammatory Activities from the Betelnut Endophytic Trichoderma asperellum G10
文献类型： 外文期刊
作者： Chen, Ming-Yang 1 ; Kong, Fan-Dong 2 ; Yang, Li 3 ; Ma, Qing-Yun 3 ; Xie, Qing-Yi 3 ; Yu, Jing 1 ; Chen, Peng-Wei 3 ; Zhou, Li-Man 2 ; Wu, You-Gen 1 ; Dai, Hao-Fu 3 ; Zhao, You-Xing 3 ;
作者机构： 1.Hainan Univ, Coll Hort, Haikou 570228, Hainan, Peoples R China
2.Guangxi Univ Nationalities, Guangxi Collaborat Innovat Ctr Chem & Engn Forest, Sch Chem & Chem Engn,Guangxi Key Lab Chem & Engn, Key Lab Chem & Engn Forest Prod,State Ethn Affair, Nanning 530006, Peoples R China
3.CATAS, Inst Trop Biosci & Biotechnol, Hainan Inst Trop Agr Resources, Haikou Key Lab Res & Utilizat Trop Nat Prod, Haikou 571101, Hainan, Peoples R China
期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.803； 五年影响因子：4.869 ）
ISSN： 0163-3864
年卷期： 2022 年 85 卷 5 期
页码：
收录情况： SCI
摘要： Eight new phenethoxy derivatives, trichoasperellinsA-H(1-8), were isolated from the endophytic fungusTrichoderma asperellumG10 isolated from the medicinal plantAreca catechuL. The structures of these compounds wereelucidated from spectroscopic data,J-based configurationalanalysis, and Mosher's methods. Compounds1-4and6-8bearone or two multioxidized C7moieties with the same carbonskeleton. The carbon skeletons of compounds6-8are new, allcontaining three moieties connected via two acetal carbons similarto those of disaccharide glycosides. Compound4inhibited nitricoxide production with an IC50value of 48.3 mu M, comparable to that of the positive control indomethacin (IC50, 42.3 mu M).
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