文献类型： 外文期刊
作者： Gan, Jianyu 1 ; Gu, Ting 1 ; Yang, Huaqiang 1 ; Ao, Zheng 2 ; Cai, Gengyuan 1 ; Hong, Linjun 1 ; Wu, Zhenfang 1 ;
作者机构： 1.South China Agr Univ, Coll Anim Sci, Natl Engn Res Ctr Breeding Swine Ind, Guangzhou 510642, Peoples R China
2.Guizhou Univ, Coll Anim Sci, Key Lab Anim Genet Breeding & Reprod Plateau Mt R, Minist Educ, Guiyang 550025, Peoples R China
3.South China Agr Univ, Coll Anim Sci, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Peoples R China
4.State Key Lab Conservat & Utilizat Subtrop Agrobi, Guangzhou 510642, Peoples R China
关键词： spontaneous abortion; miRNA; lncRNA; circRNA; competing endogenous RNA; systematic network
期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：6.208； 五年影响因子：6.628 ）
ISSN：
年卷期： 2022 年 23 卷 8 期
页码：
收录情况： SCI
摘要： Spontaneous abortion is a common pregnancy complication that negatively impacts women's health and commercial pig production. It has been demonstrated that non-coding RNA (ncRNA) is involved in SA by affecting cell proliferation, invasion, apoptosis, epithelial-mesenchymal transformation (EMT), migration, and immune response. Over the last decade, research on ncRNAs in SA has primarily concentrated on micro RNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). In this review, we discuss recent ncRNA studies focused on the function and mechanism of miRNAs, lncRNAs, and circRNAs in regulating SA. Meanwhile, we suggest that a ceRNA regulatory network exists in the onset and development of SA. A deeper understanding of this network will accelerate the process of the quest for potential RNA markers for SA diagnosis and treatment.
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