2-(2-Phenylethyl)chromone dimers as melanin production inhibitors from agarwood of Gyrinops walla Gaertn
文献类型： 外文期刊
作者： Chen, Le-Yao 1 ; Mei, Wen-Li 1 ; Yang, Li 1 ; Wu, Fei 1 ; Cai, Cai-Hong 1 ; Yuan, Jing-Zhe 1 ; Chen, Hui-Qin 1 ; Dai, Hao-Fu 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Int Joint Res Ctr Agarwood, Key Lab Res & Dev Nat Prod Li Folk Med Hainan Prov, Haikou 571101, Peoples R China
关键词： Gyrinops walla Gaertn; Agarwood; 2-(2-Phenylethyl)chromone; Tyrosinase inhibitory
期刊名称：INDUSTRIAL CROPS AND PRODUCTS （ 影响因子：6.2； 五年影响因子：6.2 ）
ISSN： 0926-6690
年卷期： 2024 年 222 卷
页码：
收录情况： SCI
摘要： Agarwood is well known to be used and traded as luxurious perfume and cosmetic traditional medicine. Gyrinops walla Gaertn, a newly discovered source of agarwood, has garnered increasing attention. Modern pharmacological studies indicated that 2-(2-phenylethyl)chromones are one of the main chemical constituents in agarwood, known for their diverse biological activities. With the aim to study the cosmetic function of 2-(2phenylethyl)chromones, phytochemical study on the agarwood from G. walla was carried out, and led to the identification of ten new 2-(2-phenylethyl)chromone dimers. All the structures were elucidated by extensive spectroscopic analysis including 1D and 2D NMR, HR-ESI-MS, as well as ECD calculation. Biological activity showed that all the compounds showed the tyrosinase inhibitory activity with IC50 values ranging from 17.70 +/- 1.47-140.30 +/- 6.43 mu M (kojic acid as the positive control with IC50 value of 24.68 +/- 0.30 mu M). The kinetic studies presented that compounds 8-10 were competitive inhibitors for tyrosinase, and molecular docking simulations revealed the binding sites and interactions of compounds 3, 4, and 10. Moreover, all the isolated compounds showed a superior inhibitory effect on melanin production in B16 cells compared to kojic acid. Therefore, 2-(2-phenylethyl)chromones could be developed to be melanin production inhibitors used as cosmetic traditional medicine.
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