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Differences in histomorphology and expression of key lipid regulated genes of four adipose tissues from Tibetan pigs

文献类型： 外文期刊

作者： Lin, Chenghong 1 ; Dong, Zexia 1 ; Song, Jia 1 ; Wang, Sutian 2 ; Yang, Ying 1 ; Li, Hua 1 ; Feng, Zheng 1 ; Pei, Yangli 1 ;

作者机构： 1.Foshan Univ, Precise Breeding Guangdong Higher Educ Inst, Sch Life Sci & Engn, Guangdong Prov Key Lab Anim Mol Design & Precise B, Foshan, Peoples R China

2.Guangdong Acad Agr Sci, Inst Anim Sci, State Key Lab Livestock & Poultry Breeding, Guangdong Key Lab Anim Breeding & Nutr, Guangzhou, Peoples R China

关键词： Tibetan pig; Adipocyte; Subcutaneous white adipose tissue; Perirenal fat; Greater omentum fat; Inguinal fat; FABP; PPAR?; C; EBP?

期刊名称：PEERJ （ 影响因子：2.7； 五年影响因子：3.1 ）

ISSN： 2167-8359

年卷期： 2023 年 11 卷

页码：

收录情况： SCI

摘要： Tibetan pigs, an indigenous pig breed in China, have high overall fat deposition and flavorful and tasty meat. They are thus good models for studying adipogenesis. Few studies have been conducted focusing on expression of lipid regulated genes in different adipose tissues of Tibetan pigs. Therefore, we compared the difference of histomorphology and expression level of lipid regulated genes through qPCR and western blot in subcutaneous fat, perirenal fat, omental adipose tissue, and inguinal fat of Tibetan pigs. Our results showed that the area of subcutaneous adipocytes in Tibetan pigs was smaller, while the other three adipose tissues (perirenal fat, greater omentum fat, inguinal fat) had cell areas of similar size. The gene expression of FABP4, FASN, FABP3, and ME1 in subcutaneous fat was significantly higher than that in perirenal fat. Furthermore, the protein expression of FABP4 was significantly lower in subcutaneous fat than in perirenal fat (p < 0.05), and the expression of FASN was higher in greater omentum fat than in subcutaneous fat (p = 0.084). The difference in adipocyte cell size and expression of lipid-regulated genes in adipose tissues from the various parts of the pig body is likely due to the different cellular lipid metabolic processes. Specially, FABP4 and FASN may be involved in the regulation of fat deposition in different adipose tissues of Tibetan pigs.

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