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Regulatory role of exosome-derived miRNAs and other contents in adipogenesis

文献类型： 外文期刊

作者： Song, Xiaoyu 1 ; Song, Yaping 1 ; Zhang, Jiupan 3 ; Hu, Yamei 1 ; Zhang, Lingkai 1 ; Huang, Zengwen 4 ; Raza, Sayed Haidar Abbas 4 ; Jiang, Chao 1 ; Ma, Yanfen 1 ; Ma, Yun 1 ; Wu, Hao 1 ; Wei, Dawei 1 ;

作者机构： 1.Ningxia Univ, Coll Anim Sci & Technol, Yinchuan 750021, Peoples R China

2.Key Lab Ruminant Mol Cell Breeding, Yinchuan 750021, Ningxia Hui Aut, Peoples R China

3.Ningxia Acad Agr & Forestry Sci, Inst Anim Sci, Yinchuan 750021, Peoples R China

4.Xichang Univ, Xichang 615000, Peoples R China

5.South China Agr Univ, Res Ctr Machining & Safety Livestock & Poultry Pro, Guangzhou 510642, Peoples R China

关键词： Exosome; miRNAs; Adipogenesis; IMF; ncRNAs; Adipose; Muscle

期刊名称：EXPERIMENTAL CELL RESEARCH （ 影响因子：3.3； 五年影响因子：3.3 ）

ISSN： 0014-4827

年卷期： 2024 年 441 卷 1 期

页码：

收录情况： SCI

摘要： Intramuscular fat (IMF) content significantly impacts meat quality. influenced by complex interactions between skeletal muscle cells and adipocytes. Adipogenesis plays a pivotal role in IMF formation. Exosomes, extracellular membranous nanovesicles, facilitate intercellular communication by transporting proteins, nucleic acids (DNA and RNA), and other biomolecules into target cells, thereby modulating cellular behaviors. Recent studies have linked exosome-derived microRNAs (miRNAs) and other cargo to adipogenic processes. Various cell types, including skeletal muscle cells, interact with adipocytes via exosome secretion and uptake. Exosomes entering adipocytes regulate adipogenesis by modulating key signaling pathways, thereby influencing the extent and distribution of IMF deposition. This review comprehensively explores the origin, formation, and mechanisms of exosome action, along with current research and their applications in adipogenesis. Emphasis is placed on exosome-mediated regulation of miRNAs, non-coding RNAs (ncRNAs), proteins, lipids, and other biomolecules during adipogenesis. Leveraging exosomal contents for genetic breeding and treating obesity-related disorders is discussed. Insights gathered contribute to advancing understanding and potential therapeutic applications of exosome-regulated adipogenesis mechanisms.

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