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Laburnicolamine: A Rare Penillic Acid Congener from the Nematode Cyst-Associated Fungus Laburnicola nematophila

文献类型： 外文期刊

作者： Wennrich, Jan-Peer 1 ; Holzenkamp, Caren 1 ; Ashrafi, Samad 4 ; Maier, Wolfgang 4 ; Wang, Hao 6 ; Ibrahim, Mahmoud A. A. 7 ; Ebada, Sherif S. 1 ; Stadler, Marc 1 ;

作者机构： 1.Helmholtz Ctr Infect Res HZI, Dept Microbial Drugs, Inhoffenstr 7, D-38124 Braunschweig, Germany

2.German Ctr Infect Res, Inhoffenstr 7, D-38124 Braunschweig, Germany

3.Tech Univ Carolo Wilhelmina Braunschweig, Inst Microbiol, Spielmannstr 7, D-38106 Braunschweig, Germany

4.Julius Kuhn Inst JKI, Inst Epidemiol & Pathogen Diagonst, Fed Res Ctr Cultivated Plants, Messeweg 11-12, D-38104 Braunschweig, Germany

5.Julius Kuhn Inst JKI, Inst Crop & Soil Sci, Fed Res Ctr Cultivated Plants, Bundesallee 58, D-38116 Braunschweig, Germany

6.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Nat Prod Res & Dev Li Folk Med Hainan Prov, Haikou 571101, Hainan, Peoples R China

7.Minia Univ, Fac Sci, Chem Dept, Computat Chem Lab, Al Minya 61519, Egypt

8.Univ KwaZulu Natal, Sch Hlth Sci, ZA-4000 Durban, South Africa

9.Ain Shams Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11566, Egypt

关键词： Laburnicola; penillic acid; penicillin G; antimicrobial

期刊名称：CHEMISTRY & BIODIVERSITY （ 影响因子：2.3； 五年影响因子：2.5 ）

ISSN： 1612-1872

年卷期： 2024 年 21 卷 8 期

页码：

收录情况： SCI

摘要： A chemical investigation of a methanol extract derived from a solid-state rice culture of the nematode-cyst associated fungus Laburnicola nematophila K01 led to the isolation and characterization of a previously undescribed penillic acid analogue named laburnicolamine (1). The chemical structure was elucidated through comprehensive 1D and 2D NMR spectroscopic analyses in methanol-d(4) and DMSO-d(6), alongside with HR-ESI-MS spectrometry. The absolute configuration of 1 was concluded through the electronic circular dichroism (ECD) and time-dependent density functional theory-ECD (TDDFT-ECD) computations compared to its acquired spectrum. Biological assays revealed that compound 1 exhibited no significant cytotoxic, antimicrobial, or nematicidal activity.

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