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Lanostane triterpenoids with anti-proliferative and PTP1B/α-glucosidase inhibitory activities from the fruiting bodies of Ganoderma calidophilum

文献类型： 外文期刊

作者： Yang, Li 1 ; Zhang, Ting-Ting 3 ; Ma, Qing-Yun 1 ; Xie, Qing-Yi 1 ; Guo, Jiao-Cen 1 ; Lu, Jia-Ju 4 ; Yu, Zhi-Fang 3 ; Dai, Hao-Fu 1 ; Zhao, You-Xing 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Key Lab Res & Dev Nat Prod Li Folk Med Hainan Prov, Haikou 571101, Peoples R China

2.Inst Trop Biosci & Biotechnol, Chinese Acad Trop Agr Sci, Natl Key Lab Trop Crop Breeding, Haikou 571101, Peoples R China

3.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Peoples R China

4.Guizhou Inst Subtrop Crops, Xingyi 562400, Guizhou, Peoples R China

关键词： Ganoderma calidophilum; Lanostane triterpenoids; PTP1B; alpha-glucosidase; Anti-proliferative activity

期刊名称：PHYTOCHEMISTRY （ 影响因子：3.8； 五年影响因子：4.0 ）

ISSN： 0031-9422

年卷期： 2023 年 215 卷

页码：

收录情况： SCI

摘要： Twelve previously undescribed and four known lanostane triterpenoids were isolated from the fruiting bodies of Ganoderma calidophilum. The structures of undescribed compounds, ganodecalones H-S (1-12), were elucidated by extensive spectroscopic analysis as well as ECD and NMR calculations. Compound 4 showed significant inhibitory activity against human leukaemia cell line K562, gastric cancer cell line SGC-7901, and cervical cancer cell line HeLa with IC50 values of 13.10 +/- 0.19, 17.26 +/- 4.75, and 4.36 +/- 0.58 mu M, respectively. Compound 16 exhibited inhibitory potency against protein tyrosine phosphatase 1B (PTP1B) and alpha-glucosidase with IC50 values of 30.2 +/- 0.13 mu M and 120.6 +/- 0.14 mu M, respectively. The binding sites and interactions of 16 with PTP1B and alpha-glucosidase were revealed using molecular docking simulations.

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