A novel aggregation-induced emission fluorescent probe to visualize peroxynitrite levels during Golgi stress
文献类型： 外文期刊
作者： Li, Jinsa 1 ; Tang, Jun 3 ; Yang, Xiaopeng 1 ; Xie, Peiyao 1 ; Liu, Jianfei 1 ; Zhang, Di 4 ; Ye, Yong 1 ;
作者机构： 1.Zhengzhou Univ, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China
2.Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China
3.Xinxiang Univ, Sch Chem & Mat Engn, Xinxiang 453003, Henan, Peoples R China
4.Henan Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Zhengzhou 450002, Peoples R China
关键词： Fluorescent probe; Monensin; Golgi apparatus; Peroxynitrite; Aggregation-induced emission
期刊名称：SENSORS AND ACTUATORS B-CHEMICAL （ 影响因子：9.221； 五年影响因子：7.676 ）
ISSN：
年卷期： 2022 年 358 卷
页码：
收录情况： SCI
摘要： Peroxynitrite (ONOO-), an endogenous reactive oxygen species (ROS), can cause a variety of diseases in organisms at high levels. Golgi oxidative stress produces a large number of ROS, and the quantitative detection of various ROS is of great significance to study Golgi oxidative stress. Therefore, accurate detection of ONOO- level in Golgi is important to reveal the mechanism of ONOO- in living organisms. Here, we developed a Golgi-targeted aggregation-induced emission (AIE) fluorescent probe Gol-ONOCA to detect ONOO- in cells. The probe Gol-ONOO- has the advantages of instant response to ONOO-, high selectivity, low detection limit (250 nM) and large Stoke's shift (180 nm). Most importantly, the probe Gol-ONOCA monitored the increase of ONOO- level caused by monensin-induced oxidative stress in the Golgi apparatus, and it was the first time to realize ONOO- imaging in the Golgi apparatus.
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