Zizaane-Type Sesquiterpenoids and Their Rearranged Derivatives from Agarwood of an Aquilaria Plant
文献类型： 外文期刊
作者： Yuan, Jing-Zhe 1 ; Yang, Yi-Ling 2 ; Li, Wei 2 ; Yang, Li 2 ; Dai, Hao-Fu 2 ; Mandi, Attila 3 ; Cai, Cai-Hong 2 ; Chen, Hui-Qin 2 ; Dong, Wen-Hua 2 ; Kurtan, Tibor 3 ; Mei, Wen-Li 2 ; Wang, Hao 2 ;
作者机构： 1.Hainan Univ, Sch Life Sci, Haikou 570228, Hainan, Peoples R China
2.Chinese Acad Trop Agr Sci, Hainan Engn Res Ctr Agarwood, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China
3.Univ Debrecen, Dept Organ Chem, POB 400, H-4002 Debrecen, Hungary
关键词： agarwood; Aquilaria sp; sesquiterpenoid; zizaane; TDDFT-ECD; anti-inflammatory effect
期刊名称：MOLECULES （ 影响因子：4.927； 五年影响因子：5.11 ）
ISSN：
年卷期： 2022 年 27 卷 1 期
页码：
收录情况： SCI
摘要： Nine new sesquiterpenoids (1-9) were isolated from ethyl ether extract of agarwood originated from Aquilaria sp., including three novel sesquiterpenoids (1-3) derived from zizaane, together with six zizaane-type sesquiterpenoids (4-9). All structures were unambiguously elucidated based on 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of sesquiterpenoids was determined by comparison of the experimental and computed ECD spectra. In vitro anti-inflammatory assessment showed that compound 9 exhibited inhibition of NO production in LPS-stimulated RAW264.7 cells with an IC50 value of 62.22 +/- 1.27 mu M.
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