文献类型： 外文期刊
作者： Chen, Ming-Yang 1 ; Xie, Qing-Yi 2 ; Kong, Fan-Dong 2 ; Ma, Qing-Yun 2 ; Zhou, Li-Man 2 ; Yuan, Jing-Zhe 2 ; Dai, Hao- 1 ;
作者机构： 1.Hainan Univ, Coll Hort, Haikou 570228, Hainan, Peoples R China
2.CATAS, Inst Trop Biosci & Biotechnol, Haikou Key Lab Res & Utilizat Trop Nat Prod, Haikou 571101, Hainan, Peoples R China
3.CATAS, Hainan Acad Trop Agr Resource, Haikou 571101, Hainan, Peoples R China
关键词： Indole-diterpenoid; marine-derived fungus; Penicillium sp; protein phoshatases inhibitory activity
期刊名称：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH （ 影响因子：1.569； 五年影响因子：1.598 ）
ISSN： 1028-6020
年卷期：
页码：
收录情况： SCI
摘要： Two new compounds named epipaxilline (1) and penerpene J (2) were isolated from the marine-derived fungus Penicillium sp. KFD28. Their structures including absolute configurations were determined on the basis of spectroscopic methods and ECD analysis. Compounds 1 and 2 showed inhibitory activities against PTP1B with IC50 values of 31.5 and 9.5 mu M, respectively, and compound 2 also showed inhibitory activities against TCPTP with IC50 value of 14.7 mu M.
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