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Insights into the degradation and toxicity difference mechanism of neonicotinoid pesticides in honeybees by mass spectrometry imaging

文献类型： 外文期刊

作者： Zhang, Yue 1 ; Chen, Dong 1 ; Du, Mingyi 1 ; Ma, Lianlian 1 ; Li, Ping 1 ; Qin, Run 1 ; Yang, Jiaru 1 ; Yin, Zhibin 3 ; Wu, 1 ;

作者机构： 1.South China Agr Univ, State Key Lab Conservat & Utilizat Subtrop Agrobi, Minist Educ, Guangzhou 510642, Peoples R China

2.South China Agr Univ, Key Lab Nat Pesticide & Chem Biol, Minist Educ, Guangzhou 510642, Peoples R China

3.Guangdong Acad Agr Sci, Agrobiol Gene Res Ctr, Guangzhou 510640, Peoples R China

4.Key Lab Biopesticide Creat & Applicat, Guangzhou 510642, Peoples R China

关键词： Neonicotinoids; Honeybees; Degradation; Synergy effect; Mass spectrometry imaging

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：6.551； 五年影响因子：6.419 ）

ISSN： 0048-9697

年卷期： 2021 年 774 卷

页码：

收录情况： SCI

摘要： Honeybees are essential for the pollination of a wide variety of crops and flowering plants, whereas they are confronting decline around the world due to the overuse of pesticides, especially neonicotinoids. The mechanism behind the negative impacts of neonicotinoids on honeybees has attracted considerable interest, yet it remains unknown due to the limited insights into the spatiotemporal distribution of pesticides in honeybees. Herein, we demonstrated the use of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDIMSI) for the spatiotemporal visualization of neonicotinoids, such as N-nitroguanidine (dinotefuran) and Ncyanoamidine (acetamiprid) compounds, administered by oral application or direct contact, in the whole-body section of honeybees. The MSI results revealed that both dinotefuran and acetamiprid can quickly penetrate various biological barriers and distribute within the whole-body section of honeybees, but acetamiprid can be degraded much faster than dinotefuran. The degradation rate of acetamiprid is significantly decreased when piperonyl butoxide (PBO) is applied, whereas that of dinotefuran remains almost unchanged. These two factors might contribute to the fact that dinotefuran affords a higher toxicity to honeybees than acetamiprid. Moreover, the toxicity and degradation rate of acetamiprid can be affected by co-application with tebuconazole. Taken together, the results presented here indicate that the discrepant toxicity between dinotefuran and acetamiprid does not lie in the difference in their of various barriers of but in the degradation rate of neonicotinoid pesticides within honeybee tissues. Moreover, new perspectives are given to better understand the causes of the current decline in honeybee populations posed by insecticides, providing guidelines for the precise use of conventional agrochemicals and the rational design of novel pesticide candidates. (C) 2021 Elsevier B.V. All rights reserved.

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