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Potential alpha-Glucosidase Inhibitors from the Deep-Sea Sediment-Derived Fungus Aspergillus insulicola

文献类型： 外文期刊

作者： Zhao, Weibo 1 ; Zeng, Yanbo 2 ; Chang, Wenjun 2 ; Chen, Huiqin 2 ; Wang, Hao 2 ; Dai, Haofu 2 ; Lv, Fang 1 ;

作者机构： 1.Beijing Inst Technol, Sch Life Sci, Beijing Key Lab Separat & Anal Biomed & Pharmaceut, Beijing 100081, Peoples R China

2.Chinese Acad Trop Agr Sci, Hainan Prov Key Lab Funct Components Res & Utiliza, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

3.Hainan Inst Trop Agr Resources, Key Lab Biol & Genet Resources Trop Crops Hainan P, Haikou 571101, Peoples R China

4.Chinese Acad Trop Agr Sci, Zhanjiang Expt Stn, Zhanjiang 524013, Peoples R China

关键词： marine fungus; Aspergillus insulicola; phenolic compounds; ECD calculations; alpha-glucosidase inhibition

期刊名称：MARINE DRUGS （ 影响因子：5.4； 五年影响因子：5.5 ）

ISSN：

年卷期： 2023 年 21 卷 3 期

页码：

收录情况： SCI

摘要： Three new phenolic compounds, epicocconigrones C-D (1-2) and flavimycin C (3), together with six known phenolic compounds: epicocconigrone A (4); 2-(10-formyl-11,13-dihydroxy-12-methoxy-14-methyl)-6,7-dihydroxy-5-methyl-4-benzofurancarboxaldehyde (5); epicoccolide B (6); eleganketal A (7); 1,3-dihydro-5-methoxy-7-methylisobenzofuran (8); and 2,3,4-trihydroxy-6-(hydroxymethyl)-5-methylbenzyl-alcohol (9), were isolated from fermentation cultures of a deep-sea sediment-derived fungus, Aspergillus insulicola. Their planar structures were elucidated based on the 1D and 2D NMR spectra and HRESIMS data. The absolute configurations of compounds 1-3 were determined by ECD calculations. Compound 3 represented a rare fully symmetrical isobenzofuran dimer. All compounds were evaluated for their a-glucosidase inhibitory activity, and compounds 1, 4-7, and 9 exhibited more potent a-glucosidase inhibitory effect with IC50 values ranging from 17.04 to 292.47 mu M than positive control acarbose with IC50 value of 822.97 mu M, indicating that these phenolic compounds could be promising lead compounds of new hypoglycemic drugs.

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