Novel Bioactive Natural Products from Marine-Derived Penicillium Fungi: A Review (2021-2023)
文献类型： 外文期刊
作者： Lv, Fang 1 ; Zeng, Yanbo 2 ;
作者机构： 1.Beijing Inst Technol, Sch Life Sci, Beijing Key Lab Separat & Anal Biomed & Pharmaceut, Beijing 100081, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Prov Key Lab Funct Components Res & Utiliza, Haikou 571101, Peoples R China
3.Chinese Acad Trop Agr Sci, Natl Key Lab Trop Crop Breeding, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China
关键词： marine-derived Penicillium; marine natural products; polyketides; antibacterial activity; cytotoxicity
期刊名称：MARINE DRUGS （ 影响因子：5.4； 五年影响因子：5.5 ）
ISSN：
年卷期： 2024 年 22 卷 5 期
页码：
收录情况： SCI
摘要： Marine-derived Penicillium fungi are productive sources of structurally unique and diverse bioactive secondary metabolites, representing a hot topic in natural product research. This review describes structural diversity, bioactivities and statistical research of 452 new natural products from marine-derived Penicillium fungi covering 2021 to 2023. Sediments are the main sources of marine-derived Penicillium fungi for producing nearly 56% new natural products. Polyketides, alkaloids, and terpenoids displayed diverse biological activities and are the major contributors to antibacterial activity, cytotoxicity, anti-inflammatory and enzyme inhibitory capacities. Polyketides had higher proportions of new bioactive compounds in new compounds than other chemical classes. The characteristics of studies in recent years are presented.
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