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Cytotoxic Indole-Diterpenoids from the Marine-Derived Fungus Penicillium sp. KFD28

文献类型： 外文期刊

作者： Dai, Lu-Ting 1 ; Yang, Li 2 ; Kong, Fan-Dong 3 ; Ma, Qing-Yun 2 ; Xie, Qing-Yi 2 ; Dai, Hao-Fu 4 ; Yu, Zhi-Fang 1 ; Zhao, 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Peoples R China

2.CATAS, Haikou Key Lab Res & Utilizat Trop Nat Prod, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China

3.Guangxi Univ Nationalities, Key Lab Chem & Engn Forest Prod, State Ethn Affairs Commiss,Sch Chem & Chem Engn, Guangxi Key Lab Chem & Engn Forest Prod,Guangxi C, Nanning 530006, Peoples R China

4.CATAS, Hainan Inst Trop Agr Resources, Haikou 571101, Hainan, Peoples R China

关键词： marine-derived fungus;

Penicillium sp.

; indole-diterpenoids; cytotoxicity; antibacterial activity

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

ISSN：

年卷期： 2021 年 19 卷 11 期

页码：

收录情况： SCI

摘要： Four new indole-diterpenoids, named penerpenes K-N (1-4), along with twelve known ones (5-16), were isolated from the fermentation broth produced by adding L-tryptophan to the culture medium of the marine-derived fungus Penicillium sp. KFD28. The structures of the new compounds were elucidated extensively by 1D and 2D NMR, HRESIMS data spectroscopic analyses and ECD calculations. Compound 4 represents the second example of paxilline-type indole diterpene bearing a 1,3-dioxepane ring. Three compounds (4, 9, and 15) were cytotoxic to cancer cell lines, of which compound 9 was the most active and showed cytotoxic activity against the human liver cancer cell line BeL-7402 with an IC50 value of 5.3 mu M. Moreover, six compounds (5, 7, 10, 12, 14, and 15) showed antibacterial activities against Staphylococcus aureus ATCC 6538 and Bacillus subtilis ATCC 6633.

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