Cadmium exposure triggers mitochondrial dysfunction and oxidative stress in chicken (Gallus gallus) kidney via mitochondrial UPR inhibition and Nrf2-mediated antioxidant defense activation
文献类型： 外文期刊
作者： Ge, Jing 1 ; Zhang, Cong 1 ; Sun, Yan-Chun 2 ; Zhang, Qi 1 ; Lv, Mei-Wei 1 ; Guo, Kai 1 ; Li, Jin-Long 1 ;
作者机构： 1.Northeast Agr Univ, Coll Vet Med, 600 Changjiang St Xiangfang Dist, Harbin 150030, Heilongjiang, Peoples R China
2.Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Harbin 150070, Heilongjiang, Peoples R China
3.Northeast Agr Univ, Key Lab Prov Educ Dept Heilongjiang Common Anim D, Harbin 150030, Heilongjiang, Peoples R China
4.Northeast Agr Univ, Heilongjiang Key Lab Lab Anim & Comparat Med, Harbin 150030, Heilongjiang, Peoples R China
关键词： Cadmium; Nephrotoxicity; Mitochondrial unfolded protein response; Nrf2 antioxidant defense; Mitochondrial dynamic homeostasis
期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：7.963； 五年影响因子：7.842 ）
ISSN： 0048-9697
年卷期： 2019 年 689 卷
页码：
收录情况： SCI
摘要： Cadmium (Cd) is a widespread environmental pollutant that accumulates in living systems and represents a significant global health hazard. Cd poses a toxicity threat to both human and animal health, including that of birds. Further knowledge of Cd toxicology pathways will allow for a better understanding of Cd-induced nephrotoxicity. To evaluate Cd-induced nephrotoxicity through potential oxidative damage, male chickens were treated with 0 mg/kg, 35 mg/kg or 70 mg/kg CdCl2 in diet for 90 days. Markedly, histopathology indicated renal tubular epithelial cell swelling, renal function CREA content abnormalities, biochemical and morphologic indices indicative of Cd-induced kidney injury. Cd toxicity induced the up-regulation of Nrf2 and downstream target genes that relieve oxidative stress. Meanwhile, Cd disrupted the homeostasis of trace elements and promoted oxidative damage. Cd interfered with mitochondrial unfolded protein response (UPRmt)-related factors (SIRT1, SIRT3, PGC-1 alpha, TFAM, Nrf1, and HTRA2) and disrupted the homeostasis of mitochondrial dynamics (OPA1, MINI, MFN2, Fis1 and MFF), thereby exacerbating mitochondrial structural damage and mitochondrial dysfunction. In conclusion, our study demonstrated that the nephrotoxicity of Cd exposure results in oxidative stress and mitochondrial dysfunction by activating the Nrf2 signaling pathway and inhibiting UPRmt in the kidneys. (C) 2019 Elsevier B.V. All rights reserved.
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