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Indole-Diterpenoids with Protein Tyrosine Phosphatase Inhibitory Activities from the Marine-Derived Fungus Penicillium sp. KFD28

文献类型： 外文期刊

作者： Zhou, Li-Man 1 ; Kong, Fan-Dong 2 ; Fan, Peng 1 ; Ma, Qng-Yun 2 ; Xie, Qing-Yi 2 ; Li, Jiu-Hui 2 ; Zheng, Hai-Zhou 3 ; Zh 1 ;

作者机构： 1.Hebei Univ, Minist Educ, College Life Sci, Key Lab Med Chem & Mol Diag, Baoding 071002, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou 571101, Hainan, Peoples R China

3.North China Pharmaceut Grp Corp, New Drug Res & Dev Ctr, Shijiazhuang 050015, Hebei, Peoples R China

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.05； 五年影响因子：4.603 ）

ISSN： 0163-3864

年卷期： 2019 年 82 卷 9 期

页码：

收录情况： SCI

摘要： Five new indole-terpenoids named penerpenes EI (1-5), along with seven known ones (6-12), were isolated from the marine-derived fungus Penicillium sp. KFD28 from a bivalve mollusk, Meretrix lusoria. The structures of the new compounds were elucidated from spectroscopic data and ECD spectroscopic analyses. Compound 1 was assigned as an indole-diterpenoid with a unique 6/5/5/6/6/5/5 heptacyclic ring system. Compound 2 represents an indole-diterpenoid with a new carbon skeleton derived from paxilline by the loss of three carbons (C-23/24/25). Compound 3 contains an additional oxygen atom between C-21 and C-22 compared to paxilline to form an unusual 6/5/5/6/6/7 hexacyclic ring system bearing a 1,3-dioxepane ring, which is rarely encountered in natural products. Compounds 1, 2, 4, and 6 showed inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 14, 27, 23, and 13 mu M, respectively.

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