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Three new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones and one new dimeric 2-(2-phenylethyl)chromone from agarwood of Aquilaria crassna Pierre ex Lecomte in Laos

文献类型： 外文期刊

作者： Zhao, Yang-Mei 1 ; Yang, Li 1 ; Kong, Fan-Dong 1 ; Dong, Wen-Hua 1 ; Li, Wei 1 ; Chen, Hui-Qin 1 ; Wang, Hao 1 ; Cai, Cai 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou, Hainan, Peoples R China

2.Hainan Engn Res Ctr Agarwood, Haikou, Hainan, Peoples R China

3.Dali Univ, Coll Pharm & Chem, Inst Mat Med, Dali, Peoples R China

关键词： Agarwood; Aquilaria crassna Pierre ex Lecomte (Thymelaeaceae); 5; 6; 7; 8-tetrahydro-2-(2-phenylethyl)chromone; cytotoxicity

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）

ISSN： 1478-6419

年卷期：

页码：

收录情况： SCI

摘要： Three new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones and one new dimeric 2-(2-phenylethyl)chromone were isolated from the agarwood of Aquilaria crassna Pierre ex Lecomte in Laos. The structures of the isolates were elucidated by spectroscopic methods, and their configurations were determined via ROESY correlations, (3)J(H-H) coupling constants analyses, comparisons of chemical shifts and specific rotations with known compounds, and ECD calculation in the case of 1. Compounds 1?4 were evaluated for their cytotoxicity. Compounds 1 and 2 exhibited weak cytotoxicity toward HeLa cell line (IC50: 49.8???1.2??M) and K562 cell line (IC50: 42.66???0.47??M), respectively.

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