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A New Polyketide-Derived Metabolite with PTP1B Inhibitory Activity from the Endophytic Fungus Pestalotiopsis neglecta

文献类型： 外文期刊

作者： Gao, Wen-Bin 1 ; Han, Li-Ping 1 ; Xie, Fei-Xiang 2 ; Ma, Qing-Yun 3 ; Li, Xiao-Fang 1 ; Zhang, Jun 1 ; Zhao, You-Xing; 1 ;

作者机构： 1.Hebei Univ, Coll Life Sci, Key Lab Med Chem & Mol Diag, Minist Educ, Baoding 071002, Peoples R China

2.Hebei Univ, Coll Pharmaceut Sci, Key Lab Pharmaceut Qual Control Hebei Prov, Baoding 071002, Peoples R China

3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China

关键词： Pestalotiopsis neglecta; polyketide-derived metabolite; PTP1B inhibitory activity

期刊名称：CHEMISTRY OF NATURAL COMPOUNDS （ 影响因子：0.809； 五年影响因子：0.708 ）

ISSN： 0009-3130

年卷期： 2019 年 55 卷 6 期

页码：

收录情况： SCI

摘要： A new polyketide-derived metabolite, named neglectine A, was isolated from cultures of the endophytic fungus Pestalotiopsis neglecta. Its structure was elucidated by analysis of 1D and 2D spectroscopic data as well as MS. Neglectine A possessed a rare bis-tetrahydrofuran ring system and showed moderate activities against SHP1, CDC25B, and PTP1B, with IC50 value of 17.1 mu g/mL, 24.0 mu g/mL, and 6.7 mu g/mL, respectively. It is important to note that neglectine A has exhibited significant selectivity between PTP1B and CDC25B, LAR, SHP1, and SHP2. This is the first time that neglectine A is reported to have significant PTP1B inhibitory action.

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