文献类型： 外文期刊
作者： Yang, Yi-Ling 2 ; Li, Wei 1 ; Wang, Hao 1 ; Yang, Li 1 ; Yuan, Jing-Zhe 1 ; Cai, Cai-Hong 1 ; Chen, Hui-Qin 1 ; Dong, Wen 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Hainan Engn Res Ctr Agarwood, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China
2.Dali Univ, Pharm & Chem Coll, Dali 671000, Peoples R China
3.Univ Debrecen, Dept Organ Chem, POB 400, H-4002 Debrecen, Hungary
关键词： Aquilaria sp.; Sesquiterpenoid; Prezizaane; alpha-Glucosidase inhibitory activity; TDDFT-ECD
期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）
ISSN： 0367-326X
年卷期： 2019 年 138 卷
页码：
收录情况： SCI
摘要： Ten new tricyclic prezizaane types sesquiterpenoids (1-10) were isolated from ethyl ether extract of agarwood originated from Aquilaria sp. Their structures were unambiguously elucidated on the basis of 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of the new prezizaenes 1, 2 and 4 was determined by single-crystal X-ray diffraction, while TDDFT-ECD method was applied for 6. Compounds 4 and 5 displayed significant inhibitory activities toward alpha-glucosidase with IC50 values of 0.22 and 1.99 mM, respectively.
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