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Antibacterial stilbenes from the tubers of Bletilla striata

文献类型： 外文期刊

作者： Jiang, Sai 1 ; Chen, Chang-Fen 1 ; Ma, Xiao-Pan 1 ; Wang, Meng-Yun 2 ; Wang, Wei 2 ; Xia, Yu 6 ; Zhang, Ni 1 ; Wu, Ming-K 1 ;

作者机构： 1.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Guizhou, Peoples R China

2.Hunan Univ Chinese Med, Sch Pharm, Innovat Mat Med Res Inst, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Hunan, Peoples R China

3.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Guizhou, Peoples R China

4.Chinese Acad Sci, Guizhou Prov Engn Res Ctr Nat Drugs, Guiyang 550014, Guizhou, Peoples R China

5.Guizhou Acad Agr Sci, Inst Modern Chinese Herbal, Guiyang 550006, Guizhou, Peoples R China

6.Anlong Xinman Biotechnol Co Ltd, Anlong 552400, Peoples R China

关键词： Bletilla striata; Stilbenoids; Bibenzyls; Phenanthrenes; Antibacterial activities

期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）

ISSN： 0367-326X

年卷期： 2019 年 138 卷

页码：

收录情况： SCI

摘要： Three new bibenzyl derivatives (bletstrins A-C, 1 3), including two bibenzyls that have hydroxyl-substituted chiral centers on the aliphatic bibenzyl bridge, along with eighteen known stilbenoids (4-21) were isolated from the tubers of Bletilln striata. The structures of new compounds were elucidated by the use of 1D/2D NMR spectroscopic data. The absolute configurations of bletitrins A and B were determined by optical rotation value. Compounds 13-16 were isolated from the Orchidaceae for the first time. Most of the isolated compounds were evaluated for their antibacterial activities against three gram-positive bacterial strains and one gram-negative bacterial strain. Compounds 4, 10, 12, 14, 15, 16 and 18 showed potent inhibitory activities, with MICs of (6-52 mu g/mL) against S. aureus ATCC 6538.

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