文献类型： 外文期刊
作者： Ran, Hong-Ling 1 ; Huang, Sheng-Zhuo 2 ; Wang, Hao 2 ; Yang, Li 2 ; Yu, Miao 2 ; Gai, Cui-Juan 2 ; Duan, Rui-Jun 2 ; Dai, Hao-Fu 2 ; Guan, Ya-Li 1 ; Mei, Wen-Li 2 ;
作者机构： 1.Hainan Normal Univ, Coll Life Sci, Key Lab Trop Anim & Plant Ecol Hainan Prov, Minist Educ Key Lab Ecol Trop Isl, Haikou 571158, Hainan, Peoples R China
2.Chinese Acad Trop Agr Sci, Hainan Key Lab Res & Dev Nat Product Li Folk Med, Hainan Inst Trop Agr Resources, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China
关键词： Strophanthus divaricatus; Aromadendrane; Sesquiterpenoid; Cytotoxicity
期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.873； 五年影响因子：1.875 ）
ISSN： 1874-3900
年卷期： 2021 年 46 卷
页码：
收录情况： SCI
摘要： Three new aromadendrane-type sesquiterpenoids (1-3) and five known compounds (4-8) were isolated from the stems of Strophanthus divaricatus. Their structures were determined by spectroscopic methods including HR-ESIMS, 1D and 2D NMR. The absolute configurations of 1-3 was determined by comparison of the experimental and computed ECD spectra. Neridienone A (6) exhibited significant cytotoxicity against human cancer cell lines BEL7402, SGC-7901, K562, A549, and HeLa with IC50 values of 3.30 +/- 0.01, 2.25 +/- 0.01, 2.02 +/- 0.03, 1.55 +/- 0.01, 4.73 +/- 0.07 isM, respectively.
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