文献类型： 外文期刊
作者： Ran, Hong-Long 1 ; Huang, Sheng-Zhuo 1 ; Wang, Hao 1 ; Yang, Li 1 ; Gai, Cui-Juan 1 ; Duan, Rui-Jun 1 ; Dai, Hao-Fu 1 ; Guan, Ya-Li 3 ; Mei, Wen-Li 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Res & Dev Nat Prod Li Folk Med Hainan Prov, Haikou 571101, Peoples R China
2.Hainan Inst Trop Agr Resources, Key Lab Conservat & Utilizat Trop Agrobioresources, Haikou 571101, Peoples R China
3.Hainan Normal Univ, Coll Life Sci, Minist Educ Key Lab Ecol Trop Isl, Key Lab Trop Anim & Plant Ecol Hainan Prov, Haikou 571158, Peoples R China
关键词： Strophanthus divaricatus; Apocynaceae; Cardiac glycosides; C (21) pregnane; Cytotoxicity
期刊名称：PHYTOCHEMISTRY （ 影响因子：3.8； 五年影响因子：4.0 ）
ISSN： 0031-9422
年卷期： 2023 年 210 卷
页码：
收录情况： SCI
摘要： Phytochemical investigation on the stems of Strophanthus divaricatus led to the isolation of four undescribed cardiac glycosides and one undescribed C21 pregnane, together with eleven known steroids. Their structures were elucidated by a comprehensive analysis of HRESIMS, 1D and 2D NMR spectra. The absolute configuration of 16 was determined by comparison of the experimental and computed ECD spectra. Compounds 1-13 and 15 displayed potent to significant cytotoxicity against human cancer cell lines K562, SGC-7901, A549 and HeLa with IC50 values of 0.02-16.08, 0.04-23.13, 0.06-22.31 and 0.06-15.13 & mu;M, respectively.
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