您好，欢迎访问中国热带农业科学院 机构知识库！
中国热带农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

One new lignan and one new fluorenone from Dendrobium nobile Lindl

文献类型： 外文期刊

作者： Cao, Xue 1 ; Yang, Li 1 ; Dai, Hao-Fu 1 ; Wei, Yan-Mei 1 ; Huang, Sheng-Zhuo 1 ; Wang, Hao 1 ; Cai, Cai-Hong 1 ; Wang, Li 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

2.Chinese Acad Trop Agr Sci, Hainan Inst Trop Agr Resources, Haikou 571101, Peoples R China

3.Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, Univ Str 1, D-40225 Dusseldorf, Germany

关键词： Dendrobium nobile Lindl; alpha-Glucosidase; Lignan; Fluorenone

期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.679； 五年影响因子：1.861 ）

ISSN： 1874-3900

年卷期： 2021 年 44 卷

页码：

收录情况： SCI

摘要： Two new compounds, dendronobilate (1) and 4-O-demethyl-nobilone (2), together with one known fluorenone were isolated from the aerial parts of Dendrobium nobile Lindl. Their structures were characterized by detailed analysis of 1D and 2D NMR spectra, HRESIMS and ECD spectra. Compounds 1-3 showed significant alpha-glucosidase inhibitory activity with IC50 values of 27.46 +/- 3.14, 4.52 +/- 0.33, and 10.78 +/- 2.05 mu M, respectively, which were superior to the acarbose (745.9 +/- 3.3 mu M). The binding interactions of 1 and 2 with alpha-glucosidase were investigated using molecular docking simulations. In addition, compound 2 exhibited potent inhibitory effect on NO production in LPS activated RAW264.7 cells with the IC50 value of 35.40 +/- 1.77 mu M without cytotoxicity observed.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国热带农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台