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Diverse indole-diterpenoids with protein tyrosine phosphatase 1B inhibitory activities from the marine coral-derived fungus Aspergillus sp. ZF-104

文献类型： 外文期刊

作者： Zhang, Fei 1 ; Yang, Li 1 ; Xie, Qing-Yi 1 ; Guo, Jiao-Cen 1 ; Ma, Qing-Yun 1 ; Dai, Lu-Ting 1 ; Zhou, Li-Man 3 ; Dai, Hao-Fu 1 ; Kong, Fan-Dong 3 ; Luo, Du-Qiang 4 ; Zhao, You-Xing 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Res & Dev Nat Prod Li Folk Med Hainan Prov, Haikou 571101, Peoples R China

2.Chinese Acad Trop Agr Sci, Natl Key Lab Trop Crop Breeding, Haikou 571101, Peoples R China

3.Guangxi Minzu Univ, Guangxi Collaborat Innovat Ctr Chem & Engn Forest, Sch Chem & Chem Engn,Guangxi Key Lab Chem & Engn, Key Lab Chem & Engn Forest Prod, Nanning 530006, Peoples R China

4.Hebei Univ, Coll Life Sci, Key Lab Med Chem & Mol Diag, Minist Educ, Baoding 071002, Peoples R China

关键词： Coral-derived fungus; Aspergillus sp. ZF-104; Indole-diterpenoids; PTP1B inhibitory activity; Molecular docking

期刊名称：PHYTOCHEMISTRY （ 影响因子：3.8； 五年影响因子：4.0 ）

ISSN： 0031-9422

年卷期： 2023 年 216 卷

页码：

收录情况： SCI

摘要： Eight previously undescribed indole-diterpenoids named penerpenes O-V (1-8), together with seven known analogues (9-14), were isolated from the marine soft coral-derived fungus Aspergillus sp. ZF-104. Their structures including the absolute configurations of these compounds were assigned on the basis of spectroscopic data and ECD analysis along with quantum ECD and NMR calculations. Compounds 4 and 5 bear rare indolin-2-one units in their structures and 6 bears a reconstructed novel skeleton in which the indole ring and the terpenoid substructure are cleaved before they are reconnected through the nitrogen atom. Compounds 1, 2, 7, and 10 showed protein tyrosine phosphatase 1B (PTP1B) inhibitory activities comparable to that of the positive control NaVO3.

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