Filarones A and B, new anti-inflammatory dimeric 2-(2-phenethyl) chromones from agarwood of Aquilaria filaria
文献类型： 外文期刊
作者： Liu, Fang-Zheng 1 ; Wang, Hao 2 ; Li, Wei 2 ; Yang, Li 2 ; Yang, Jin-Ling 2 ; Yuan, Jing-Zhe 2 ; Wei, Yan-Mei 2 ; Jiang, Bei 1 ; Mei, Wen -Li 2 ; Dai, Hao-Fu 2 ;
作者机构： 1.Dali Univ, Coll Pharm, Dali 671003, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Engn Res Ctr Agarwood, Haikou 571101, Hainan, Peoples R China
关键词： Thymelaeaceae; Aquilaria filarial; Agarwood; Filarone; Anti-inflammatory activity
期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.873； 五年影响因子：1.875 ）
ISSN： 1874-3900
年卷期： 2021 年 46 卷
页码：
收录情况： SCI
摘要： Two new dimeric 2-(2-phenethyl)chromones (filarones A and B) were isolated from agarwood of Aquilaria filaria (Thymelaeaceae) by LC-MS-guided fractionation procedure. Their structures were established based on spec-troscopic methods including HRESIMS, one and two dimensional NMR. Filarones A and B exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells with IC50 values of 11.33 +/- 1.76 mu M and 10.69 +/- 0.18 mu M. Quercetin and indomethacin were used as positive controls with IC50 values of 8.22 +/- 0.80 mu M and 35.40 +/- 1.77 mu M, respectively.
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