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Expression of dysregulated miRNA in vivo in DF-1 cells during the course of subgroup J avian leukosis virus infection

文献类型： 外文期刊

作者： Ji, Jun 1 ; Xu, Xin 1 ; Wang, Xueyu 1 ; Yao, Lunguang 1 ; Shang, Huiqin 2 ; Li, Hongxin 2 ; Ma, Jingyun 2 ; Bi, Yingzuo 2 ;

作者机构： 1.Nanyang Normal Univ, China UK NYNURRes Joint Lab Insect Biol, Nanyang 473061, Henan, Peoples R China

2.Minist Agr, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Guangdong, Peoples R China

3.Minist Agr, Key Lab Chicken Genet Breeding & Reprod, Guangzhou 510642, Guangdong, Peoples R China

4.Guangdong Prov Dept Sci & Technol, Key Lab Anim Hlth Aquaculture & Environm Control, Guangzhou 510642, Guangdong, Peoples R China

5.South China Agr Univ, Coll Anim Sci, Guangzhou 510642, Guangdong, Peoples R China

关键词： ALV-J; Expression change; miRNA; DF-1 cells; Pathway prediction

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.663 ）

ISSN： 0882-4010

年卷期： 2019 年 126 卷

页码：

收录情况： SCI

摘要： Aberrant expression of microRNAs (miRNAs) is known to be involved in cancer progression caused by subgroup J avian leukosis virus (ALV-J) in liver tissues. To advance our understanding of the related pathological mechanisms and virus-host interactions, seven previously reported miRNAs were selected for a comparative analysis of miRNA expression between infected and uninfected DF-1 cells, including six miRNAs related to tumorigenesis (let-7b/7i, miR-221/222, miR-125b, miR-375 and miR-2127. The results showed that six of the seven miRNAs except gga-miR-375 were upregulated in cells infected with NX0101 (caused myeloma (ML)) and GD1109 (caused hemangioma (HE)) at 1 h post infection. On day 2 post-infection, all seven miRNAs were upregulated in infected DF-1 cells. On day 6 post-infection, gga-let-7b, gga-miR-125b, and gga-miR-375 were downregulated whereas gga-miR-221 and gga-miR-222 were upregulated in DF-1 cells infected with the two ALV-J strains of different phenotypes. However, expression of gga-let-7i was reduced in DF-1 cells infected with NX0101 and was increased in those infected with GD1109; gga-miR-2127 expression showed no significant difference between infected and uninfected cells. This study is the first to report the changes in the miRNA expression levels in DF-1 cells during the course of ALV-J infection, and suggests a relationship between its pathological mechanisms and miRNAs.

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