Carotane-type sesquiterpenes from cultures of the insect pathogenic fungus Isaria fumosorosea
文献类型： 外文期刊
作者： Zhang, Jun 1 ; Liu, Sha-Sha 1 ; Yuan, Wei-Yu 1 ; Wei, Jing-Jing 3 ; Zhao, You-Xing 2 ; Luo, Du-Qiang 1 ;
作者机构： 1.Hebei Univ, Coll Life Sci, Minist Educ, Key Lab Med Chem & Mol Diag, Baoding 071002, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China
3.Hebei Univ, Coll Pharmaceut Sci, Key Lab Pharmaceut Qual Control Hebei Prov, Baoding 071002, Peoples R China
关键词： Isaria fumosorosea; carotane sesquiterpenes; cytotoxicity
期刊名称：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH （ 影响因子：1.569； 五年影响因子：1.598 ）
ISSN： 1028-6020
年卷期： 2019 年 21 卷 3 期
页码：
收录情况： SCI
摘要： Two new carotane-type sesquiterpenes named trichocaranes E (1) and F (2), along with two known ones CAF-603 (3) and trichocarane C (4), were isolated from cultures of the insect pathogenic fungus Isaria fumosorosea. Their structures and relative configurations were elucidated by extensive spectroscopic analysis and X-ray crystallography. Compounds 1-3 showed potent cytotoxic activities against six tumor cell lines MDA, MCF-7, SKOV-3, Hela, A549, HepG2 with IC50 values in a concentration range of 0.1-6.0 mu g/ml. [GRAPHICS]
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