Expression profile analysis of microRNAs during hair follicle development in the sheep foetus
文献类型： 外文期刊
作者： Yang, Han-Yu-Lu 1 ; Yang, Hua 2 ; Shi, Guo-Qing 2 ; Shen, Min 2 ; Yang, Jing-Quan 2 ; Yang, Yong-Lin 2 ; Liu, Xiao-Jun 1 ;
作者机构： 1.Shihezi Univ, Coll Anim Sci & Technol, Shihezi, Peoples R China
2.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi, Peoples R China
3.Henan Agr Univ, Coll Anim Sci & Vet Med, Zhengzhou, Henan, Peoples R China
关键词： Hair follicle; microRNAs; development; high-throughput sequencing
期刊名称：BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY （ 影响因子：2.043； 五年影响因子：2.017 ）
ISSN： 0916-8451
年卷期： 2019 年 83 卷 6 期
页码：
收录情况： SCI
摘要： MicroRNAs (miRNAs) regulate the development and growth cycle of hair follicles (HFs). The molecular mechanism by which miRNAs determine the development of HFs in the sheep foetus remains elusive. In this study, the expression profiles of miRNAs at 11 development periods (45, 55, 65, 75, 85, 95, 105, 115, 125, 135 and 145 d) in sheep foetus skin were analysed by high-throughput sequencing and bioinformatics analysis. A total of 72 conserved miRNAs, 44 novel miRNAs and 32 known miRNAs were significantly differentially expressed. qRT-PCR results for 18 miRNAs were consistent with the sequencing data. 85 d of foetal development was the starting point for secondary hair follicle (SF) development according to tissue morphology and cluster analysis. In SF development, the prolactin signalling pathway and platelet activation played important roles, and 10 miRNAs were potential candidate miRNAs in SF initiation.
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