Five new epoxy-5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones from Chinese agarwood by artificial holing
文献类型： 外文期刊
作者： Li, Wei 1 ; Liao, Ge 1 ; Wang, Hao 1 ; Dong, Wen-Hua 1 ; Yang, Li 1 ; Kong, Fan-Dong 1 ; Cai, Cai-Hong 1 ; Wang, Jun 1 ; Man 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Hainan, Peoples R China
2.Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou 571101, Hainan, Peoples R China
3.Hainan Engn Res Ctr Agarwood, Haikou 571101, Hainan, Peoples R China
4.Univ Debrecen, Dept Organ Chem, POB 400, H-4002 Debrecen, Hungary
关键词： Agarwood; Artificial holing; Chiral tetrahydrochromone; TDDFT-ECD; AChE inhibitory activity
期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）
ISSN： 0367-326X
年卷期： 2019 年 134 卷
页码：
收录情况： SCI
摘要： Five optically active epoxy-5,6,7,8-tetrahydro-2-(2-phenylethyl)chromone derivatives (1-5) with four chirality centers in the condensed cyclohexene ring were isolated from artificial holing agarwood originating from Aquilaria sinensis (Lour.) Gilg. Their structures were elucidated by spectroscopic techniques (UV, IR, 1D and 2D NMR) and MS analyses. The absolute configuration of 2 was elucidated by TDDFT-ECD calculations and ECD spectra of 1, 3-5 allowed their configurational assignment as well. All of the new compounds contained a condensed oxirane ring, and compound 1 was the only 6,7-epoxy-2-(2-phenylethyl)-5,6,7,8-tetrahydrochromone derivative that has ever been found in agarwood. AChE inhibitory activity was tested for the first time of these new compounds by using modified Ellman's colorimetric method. Compounds 3 and 5 exhibited inhibitory activity against AChE with IC50 value of 441.6, and 155.6 mu M, respectively.
- 相关文献
作者其他论文 更多>>
-
New Isocoumarins from an Endophytic Fungal Strain Diaporthe arengae M2 and their Antibacterial Activities
作者：Liu, De-Sui;Ma, Qing-Yun;Yang, Li;Xie, Qing-Yi;Dai, Hao-Fu;Zhao, You-Xing;Liu, De-Sui;Ma, Qing-Yun;Yang, Li;Xie, Qing-Yi;Dai, Hao-Fu;Zhao, You-Xing;Liu, De-Sui;Zhang, Jun-Feng;Wu, You-Gen
关键词：Endophytic fungi;
Diaporthe sp.; Isocoumarin derivatives; Antibacterial activity -
Identification of targets and comparative study of administration methods for the lipid-lowering effects of fucoidan from Saccharina japonica
作者：Chen, Pengwei;Wang, Hao;Chen, Huiqin;Dai, Haofu;Hao, Li;Li, Quancai;Zhang, Miao;Jiang, Hongfei;Zhang, Renshuai;Jia, Ang
关键词：Fucoidan; Lipid-lowering activity; Dietary supplementation; Intestinal target; Gut microbiota
-
Foisc1 regulates growth, conidiation, sensitivity to salicylic acid, and pathogenicity of Fusarium oxysporum f. sp. cubense tropical race 4
作者：Guo, Lijia;Wang, Jun;Zhou, You;Liang, Changcong;Liu, Lei;Yang, Yang;Huang, Junsheng;Yang, Laying;Guo, Lijia;Wang, Jun;Zhou, You;Liang, Changcong;Liu, Lei;Yang, Yang;Huang, Junsheng;Yang, Laying;Guo, Lijia;Wang, Jun;Zhou, You;Liang, Changcong;Liu, Lei;Yang, Yang;Huang, Junsheng;Yang, Laying;Guo, Lijia;Wang, Jun;Zhou, You;Liang, Changcong;Liu, Lei;Yang, Yang;Huang, Junsheng;Yang, Laying
关键词：Vascular wilt of banana; Isochorismatase; Pathogenicity; Salicylic acid; Defense response; Fusaric acid biosynthesis
-
Colonization time of plastisphere drives the dynamics of organic carbon stability and microbial communities in seagrass bed sediments
作者：Hou, Shuailing;Wang, Jun;Feng, Dan;Fan, Jinluo;Luo, Mingguang;Deng, Hui;Yang, Xing;Luo, Jiwei;Zhao, Yuanyuan;Ge, Chengjun;Hou, Shuailing;Wang, Jun;Feng, Dan;Fan, Jinluo;Luo, Mingguang;Deng, Hui;Yang, Xing;Luo, Jiwei;Zhao, Yuanyuan;Ge, Chengjun;Hou, Shuailing;Wang, Jun;Feng, Dan;Fan, Jinluo;Luo, Mingguang;Deng, Hui;Yang, Xing;Luo, Jiwei;Zhao, Yuanyuan;Ge, Chengjun;Wu, Dongming;Chen, Shiquan;Feng, Dan
关键词：Plastisphere; Seagrass bed sediments; Organic carbon stability; Colonization time; Bacterial community
-
Comprehensive analysis of morphology, transcriptomics, and metabolomics of banana (Musa spp.) molecular mechanisms related to plant height
作者：Wei, Junya;Cheng, Shimin;Huang, Lina;Wei, Shouxing;Liu, Guoyin;Sun, Mingzhen;Wang, Hao;Liu, Debing;Yang, Ping
关键词：banana; metabolomics; transcriptomics; hormones; height
-
2-(2-Phenylethyl)chromone-Sesquiterpene Hybrids from Agarwood of Aquilaria sinensis: Characterization and Biological Activity Evaluation
作者：Xu, Guan-Hua;Liu, Shou-Bai;Xu, Guan-Hua;Wang, Ya-Li;Wang, Hao;Chen, Hui-Qin;Dong, Wen-Hua;Huang, Sheng-Zhuo;Cai, Cai-Hong;Yuan, Jing-Zhe;Mei, Wen-Li;Dai, Hao-Fu
关键词：Hainan agarwood; 2-(2-phenylethyl)chromone-sesquiterpene hybrids; structure elucidation; anti-inflammatory activity; neuroprotective activity; cytotoxic activity
-
Three new dimeric 2-(2-phenethyl)chromones from the agarwood of Aquilaria malaccensis
作者：Yan, Xian-Yun;Liang, Lin-Fu;Yan, Xian-Yun;Li, Wei;Wang, Hao;Dong, Wen-Hua;Zeng, Jun;Wu, Fei;Mei, Wen-Li;Dai, Hao-Fu;Yan, Xian-Yun;Li, Wei;Wang, Hao;Dong, Wen-Hua;Zeng, Jun;Wu, Fei;Mei, Wen-Li;Dai, Hao-Fu
关键词：Agarwood; Aquilaria malaccensis; 2-(2-phenethyl)chromone dimers; Anti-inflammatory activity
