文献类型： 外文期刊
作者： Mi, Cheng-Neng 1 ; Mei, Wen-Li 2 ; Wang, Hao 2 ; Yang, Li 2 ; Dong, Wen-Hua 1 ; Gai, Cui-Juan 2 ; Yuan, Jing-Zhe 1 ; Long 1 ;
作者机构： 1.Hainan Univ, Inst Trop Agr & Forestry, 58 Peoples Ave, Haikou 570228, Hainan, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Hainan, Peoples R China
3.Hainan Engn Res Ctr Agarwood, Haikou 571101, Hainan, Peoples R China
关键词： Aquilaria filaria; Agarwood; Sesquiterpenoid; 2-(2-phenylethyl)chromone; Cytotoxicity; alpha-Glucosidase inhibitory activity
期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）
ISSN： 0367-326X
年卷期： 2019 年 135 卷
页码：
收录情况： SCI
摘要： Six 8,12-epoxyguaiane sesquiterpenes (1-6), together with two known 2-(2-phenylethyl)chromone derivatives (7-8) were isolated from agarwood originating from Aquilaria filaria. Their structures were established by spectroscopic methods including IR, HRESIMS, 1D, and 2D NMR, and comparison with the published data. The absolute configuration of compound 1 was unambiguously determined by quantum chemical calculation of the electronic circular dichroism (ECD) spectrum. All compounds were tested for their alpha-glucosidase inhibitory activity and cytotoxicity. Compound 5 showed significant alpha-glucosidase inhibitory activity with IC50 value of 253.2 +/- 9.7 mu M (Acarbose, 743. +/- 4 3.3 mu M). Compounds 2-4 displayed weak cytotoxicity against K562 tumor cell lines.
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