Penerpenes A-D, Four Indole Terpenoids with Potent Protein Tyrosine Phosphatase Inhibitory Activity from the Marine-Derived Fungus Penicillium sp. KFD28
文献类型： 外文期刊
作者： Kong, Fan-Dong 1 ; Fan, Peng 2 ; Zhou, Li-Man 2 ; Ma, Qing-Yun 1 ; Xie, Qing-Yi 1 ; Zheng, Hai-Zhou 3 ; Zheng, Zhi-Hui 3 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Res & Dev Nat Prod Li Folk Med, Haikou 571101, Hainan, Peoples R China
2.Hebei Univ, Coll Life Sci, Key Lab Med Chem & Mol Diag, Minist Educ, Baoding 071002, Peoples R China
3.North China Pharmaceut Grp Corp, New Drug Res & Dev Ctr, Shijiazhuang 050015, Hebei, Peoples R China
4.Qingdao Univ, Affiliated Hosp, Qingdao Canc Inst, Qingdao 266061, Shandong, Peoples R China
期刊名称：ORGANIC LETTERS （ 影响因子：6.005； 五年影响因子：5.551 ）
ISSN： 1523-7060
年卷期： 2019 年 21 卷 12 期
页码：
收录情况： SCI
摘要： Four unusual indole-terpenoids, penerpenes A-D (1-4), along with two known ones paxilline (5) and emindole SB (6), were isolated from the marine-derived fungus Penicillium sp. KFD28. The absolute structures of 1-4 were elucidated on the basis of spectroscopic data and ECD spectra analysis along with quantum ECD calculations. Compounds 1 and 2 showed potent inhibitory activity toward protein tyrosine phosphatases (PTP1B and TCPTP). Plausible biosynthetic pathways of compounds 1-4 are proposed.
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