CYANIDIN AND PEONIDIN INHIBIT SPCA-1 GROWTH IN VITRO VIA INDUCING CELL CYCLE ARREST AND APOPTOSIS
文献类型： 外文期刊
作者： Yue, Heng 1 ; XU, Qianqian 1 ; Lv, Liuzhuang 1 ; Fan, Hua 3 ; Xu, Jianfeng 1 ; Wang, Wenhan 4 ;
作者机构： 1.Shanghai Ocean Univ, Coll Food Sci & Technol, Dept Biopharmaceut, Shanghai, Peoples R China
2.Minist Agr, Qual Supervis Inspect & Testing Ctr Cold Storage, Shanghai 201306, Peoples R China
3.Charite Univ Med Berlin, Inst Lab Med, Campus Virchow Klinikum, Berlin, Germany
4.Shanghai Acad Agr Sci, Inst Edible Fungi, Key Lab Edible Fungi Resources & Utilizat South S, Shanghai, Peoples R China
关键词： SPCA-1; cyanidin; peonidin; lung cancer; apoptosis; cell cycle
期刊名称：ACTA POLONIAE PHARMACEUTICA （ 影响因子：0.33； 五年影响因子：0.667 ）
ISSN： 0001-6837
年卷期： 2019 年 76 卷 3 期
页码：
收录情况： SCI
摘要： Non-small cell lung cancer (NSCLC) accounts for the majority (85%) of all lung cancers. Although many therapies are available, 35-50% of patients with stage I or II NSCLC develop recurrence and metastasis. This study was designed to investigate the anti-tumor activity of cyanidin (Cy) and peonidin (Pn) on NSCLC cells (SPCA-1). SPCA-1 cell proliferation, cell cycle and early apoptosis were investigated after treatment with Cy and Pn. The underlying signaling mechanism was also explored by detecting the levels of apoptosis-related proteins using enzyme-linked immunosorbent assay (ELISA). Cy and Pn inhibited the viability of SPCA-1 cells with an IC50 of 141.08 eg/mL and 161.31 mu g/mL, respectively. Meanwhile, Cy and Pn induced cell cycle arrest at G2/M phase. Cy and Pn treatment significantly increased the levels of Bax, P53, and Caspase-3, while decreasing that of Bcl-2, thereby inhibiting the growth of SPCA-1 cells. In conclusion, Cy and Pn induced early apoptosis of NSCLC cells through regulation of the levels on Caspase-3, Bax, Bcl-2, and P53. These results suggest Cy and Pn as potential anticancer drugs for the treatment of lung cancer.
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