Three new 2-(2-phenylethyl)chromone derivatives from agarwood of Aquilaria crassna Pierre ex Lecomte (Thymelaeaceae) in Laos
文献类型： 外文期刊
作者： Zhao, Yang-Mei 1 ; Yang, Li 1 ; Dong, Wen-Hua 1 ; Li, Wei 1 ; Chen, Hui-Qin 1 ; Wang, Hao 1 ; Cai, Cai-Hong 1 ; Gai, Cui- 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Hainan, Peoples R China
2.Hainan Engn Res Ctr Agarwood, Haikou 571101, Hainan, Peoples R China
3.Dali Univ, Coll Pharm & Chem, Inst Mat Med, Dali 671003, Peoples R China
关键词： Agarwood; Aquilaria crassna Pierre ex Lecomte (Thymelaeaceae); 2-(2-Phenylethyl)chromone; Tyrosinase inhibition
期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.679； 五年影响因子：1.861 ）
ISSN： 1874-3900
年卷期： 2019 年 32 卷
页码：
收录情况： SCI
摘要： In our ongoing effort to study the metabolites from agarwood of Aquilaria crassna Pierre ex Lecomte (Thymelaeaceae) produced in Laos, three new 2-(2-phenylethyl)chromone derivatives (1 - 3) were isolated. Their structures were elucidated by comprehensive spectroscopic analyses, predominantly by 1D and 2D NMR spectroscopic methods, and by comparison with the reported data. Compound 2 exhibited tyrosinase inhibitory activity with IC50, value of 172.6 +/- 1.7 mu M (kojic acid as the positive control, 46.1 +/- 1.3 mu M) and its inhibition mode was clarified by molecular modelling study. None of the isolates showed significant cytotoxicity towards tested cancer cell lines.
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