LC-MS-guided isolation of 2-(2-phenylethyl)chromone dimers from red soil agarwood of Aquilaria crassna
文献类型： 外文期刊
作者： He, Di 1 ; Dong, Wen-Hua 1 ; Li, Wei 1 ; Yang, Li 1 ; Yuan, Jing-Zhe 1 ; Gai, Cui-Juan 1 ; Cai, Cai-Hong 1 ; Dai, Hao-Fu 1 ; Wang, Hao 1 ; Mei, Wen-Li 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Hainan Engn Res Ctr Agarwood, Hainan Inst Trop Agr Resources, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China
关键词： Red soil agarwood; Aquilaria crassna; 2-(2-phenylethyl)chromone dimers; Cytotoxicity
期刊名称：FITOTERAPIA （ 影响因子：3.204； 五年影响因子：3.297 ）
ISSN： 0367-326X
年卷期： 2022 年 158 卷
页码：
收录情况： SCI
摘要： Six new 2-(2-phenylethyl)chromone dimers (1-6) were isolated from ethyl ether extract of red soil agarwood of Aquilaria crassna from Vietnam by LC-MS-guided fractionation procedure. Their structures were unambiguously elucidated based on HRESIMS, 1D and 2D NMR spectra. The absolute configuration of 2-(2-phenylethypchmmone dimers was determined by comparison of the experimental and computed ECD spectra. Compound 6 displayed cytotoxicity against the human myeloid leukemia cell line (K562) with an IC50 value of 39.49 mu M.
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