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Asperphenalenones Isolated from the Biocontrol Agent Clonostachys rosea and Their Antimicrobial Activities

文献类型： 外文期刊

作者： Wang, Lin 1 ; Kiffe-Delf, Anna-Lene 1 ; Ostermann, Philipp Niklas 2 ; Simons, Viktor Emanuel 1 ; He, Di 1 ; Gao, Ying 1 ; van Geelen, Lasse 1 ; Dai, Hao-Fu 3 ; Zhao, You-Xing 3 ; Schaal, Heiner 2 ; Mandi, Attila 4 ; Kiraly, Sandor Balazs 4 ; Kurtan, Tibor 4 ; Liu, Zhen 5 ; Kalscheuer, Rainer 1 ;

作者机构： 1.Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany

2.Heinrich Heine Univ Dusseldorf, Univ Hosp Dusseldorf, Inst Virol, D-40225 Dusseldorf, Germany

3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China

4.Univ Debrecen, Dept Organ Chem, H-4002 Debrecen, Hungary

5.Hunan Normal Univ, Sch Med, Key Lab Study & Discovery Small Targeted Mol Huna, Changsha 410013, Hunan, Peoples R China

关键词： Clonostachys rosea; asperphenalenones; antibacterial activity; methicillin-resistant Staphylococcus aureus (MRSA); anti-HIV activity

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）

ISSN： 0021-8561

年卷期： 2023 年 71 卷 29 期

页码：

收录情况： SCI

摘要： Clonostachys rosea isa fungus widelydistributed on Earth and has a high capacity to adapt to complex environmentsin soil, plants, or sea. It is an endophyte that can be used as apotential biocontrol agent to protect plants from pathogenic fungi,nematodes, and insects. However, the spectrum of secondary metabolitesproduced by C. rosea has only scarcelybeen studied. In the present study, eight new phenalenones, asperphenalenonesF-M (1-8), together with twoknown derivatives, asperphenalenones E and B (9 and 10), were isolated from the axenic rice culture of this fungus.The structures of the new compounds were elucidated by nuclear magneticresonance, high-resolution electrospray ionization mass spectrometry,electronic circular dichroism, and gas chromatography-massspectrometry analyses. Asperphenalenones J-M (5-8) are unusual phenalenone adducts that areconjugated to diterpenoid glycosides. Asperphenalenones F and H showedmoderate antibacterial activity against methicillin-resistant Staphylococcus aureus, with minimal inhibitory concentrationsof 12.5 and 25 & mu;M, respectively. Asperphenalenone B exhibitedlow antiviral activity against the human immunodeficiency virus replication.Furthermore, asperphenalenones F and H exhibited low cytotoxicityagainst Jurkat cells, while all other compounds were devoid of cytotoxicity.

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