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Anti-inflammatory and a-glucosidase inhibitory constituents from Dendrobium nobile Lindl

文献类型： 外文期刊

作者： Guo, Dong-Sheng 1 ; Cao, Xue 1 ; Chen, Hui-Qin 1 ; Wei, Yan-Mei 1 ; Wang, Hao 1 ; Cai, Cai-Hong 1 ; Dai, Hao-Fu 1 ; Yang, Li 1 ; Mei, Wen-Li 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Nat Prod Res & Dev Li Folk Med Hainan Prov, Haikou 571101, Hainan, Peoples R China

2.Hainan Acad Trop Agr Resources, Key Lab Conservat & Utilizat Trop Agrobioresources, Haikou 571101, Hainan, Peoples R China

关键词： Dendrobium nobile; Bibenzyl; & alpha;-Glucosidase inhibition; Anti-inflammatory activity; Molecular docking

期刊名称：FITOTERAPIA （ 影响因子：3.4； 五年影响因子：3.3 ）

ISSN： 0367-326X

年卷期： 2023 年 169 卷

页码：

收录情况： SCI

摘要： Four new compounds ((+/-)-1-3), including one pair of enantiomers ((+/-)-1), along with 11 known bibenzyls (4-14) were isolated from Dendrobium nobile. The structures of the new compounds were elucidated by spectroscopic methods including 1D and 2D NMR as well as HRESIMS. The configurations of (+/-)-1 were established via the electronic circular dichroism (ECD) calculations. Compounds (+)-1 and 13 displayed pronounced a-glucosidase inhibitory activities with IC50 values of 16.7 +/- 2.3 and 13.4 +/- 0.2 mu M, respectively, which were comparable to that of genistein (IC50, 8.54 +/- 0.69 mu M). Kinetic studies revealed that (+)-1 and 13 were non-competitive inhibitors against a-glucosidase and molecular docking simulations illuminated their interactions with a-glucosidase. All the isolates were also evaluated for their anti-inflammatory activities. Compounds 4, 5, and 11 exhibited superior inhibition activity with IC50 values ranging from 9.2 to 13.8 mu M to that of quercetin (IC50, 16.3 +/- 1.1 mu M).

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