Comparison of birth weight and umbilical and placental characteristics of cloned and artificial insemination-derived piglets
文献类型： 外文期刊
作者： Ao, Zheng 1 ; Zhao, Chengfa 1 ; Gan, Yanmin 1 ; Wu, Xiao 1 ; Shi, Junsong 3 ; Zheng, Enqin 1 ; Liu, Dewu 1 ; Cai, Gengyuan 1 ; Wu, Zhenfang 1 ; Li, Zicong 1 ;
作者机构： 1.South China Agr Univ, Natl Engn Res Ctr Breeding Swine Ind, Coll Anim Sci, Guangzhou 510642, Guangdong, Peoples R China
2.South China Agr Univ, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Coll Anim Sci, Guangzhou 510642, Guangdong, Peoples R China
3.Guangdong Wens Breeding Swine Co Ltd, Yunfu 527400, Peoples R China
关键词： cloned; pig; death; placenta; SCNT; umbilical cord
期刊名称：FRONTIERS OF AGRICULTURAL SCIENCE AND ENGINEERING （ 影响因子：3.7； 五年影响因子：2.7 ）
ISSN： 2095-7505
年卷期： 2019 年 6 卷 1 期
页码：
收录情况： SCI
摘要： Somatic cell nuclear transfer (SCNT)-derived piglets have significantly higher stillbirth rate and postnatal mortality rate than artificial insemination (AI)-generated piglets. The question whether the low survival rate of SCNT piglets was related to birth weight, umbilical cord or placenta development was investigated. In this study, stillbirth rate, neonatal death rate, birth weight, umbilical cord status, placental parameters and placental gene expression patterns were compared between SCNT and AI piglets. Results showed that mortality rates at birth and during the neonatal stage of SCNT piglets were significantly higher than those of AI piglets. The incidence of abnormal umbilical cord in SCNT and SCNT-liveborn (SCNT-LB) piglets was significantly higher than in AI and AI-liveborn (AI-LB) piglets. Birth weight, placental weight, placental surface area and placental efficiency in SCNT and SCNT-LB piglets were significantly lower than those of AI and AI-LB piglets. Placental expression profiles of imprinting, angiopoiesis and nutrient transportrelated genes were defective in SCNT-LB piglets compared with those in AI-LB piglets. Thus, the low survival rate of SCNT piglets may be associated with abnormal umbilical cord and placenta development. These characteristics may have resulted from aberrant expression of angiogenesis, nutrient transport, and imprinting-related genes in the placentas.
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