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Sesquiterpenoids and bibenzyl derivative from Dendrobium hercoglossum

文献类型： 外文期刊

作者： Chen, Hui-Qin 1 ; Guo, Dong-Sheng 2 ; Wang, Hao 1 ; Cai, Cai-Hong 1 ; Yuan, Jing-Zhe 1 ; Dai, Hao-Fu 1 ; Yang, Li 1 ; Mei, Wen-Li 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Natl Key Lab Trop Crop Breeding, Haikou 571101, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Nat Prod Res & Dev Li Folk Med Hainan Prov, Haikou 571101, Hainan, Peoples R China

3.Chinese Acad Forestry, Guangxi Youyiguan Forest Ecosyst Res Stn, Expt Ctr Trop Forestry, Pingxiang 532600, Guangxi, Peoples R China

关键词： Dendrobium hercoglossum; Sesquiterpenoid; Bibenzyl; Neuroprotective activity; Anti-inflammatory activity

期刊名称：FITOTERAPIA （ 影响因子：3.4； 五年影响因子：3.3 ）

ISSN： 0367-326X

年卷期： 2024 年 172 卷

页码：

收录情况： SCI

摘要： Three new sesquiterpenoids, dendrohercoglin A - C (1-3), and one new bibenzyl derivative, dendronbiline D (4), together with nine known sesquiterpenoids (5-13) were isolated from Dendrobium hercoglossum. The structures of the new compounds were elucidated by extensive spectroscopic analysis as well as NMR and ECD calculations. All the compounds were evaluated for their neuroprotective and anti-inflammatory activities. Compounds 2 and 3 increased the H2O2-damaged SH-SY5Y cell viabilities from 43.3% to 58.6% and 68.4%, respectively. Compound 4 exhibited pronounced anti-inflammatory activity with IC50 value of 9.5 +/- 0.45 mu M which was superior to the reference compound quercetin (IC50: 15.7 +/- 0.89 mu M).

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