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CHEMICAL CONSTITUENTS OF Chondrophycus papillosus AND THEIR CYTOTOXICITY IN VITRO

文献类型： 外文期刊

作者： Sun, Ling-Ling 1 ; Wang, Chang-Yun 1 ; Dai, Hao-Fu 2 ; Shao, Chang-Lun 1 ; Mei, Wen-Li 2 ; Tao-Liu 3 ; Ma, Ze-Dong 1 ;

作者机构： 1.Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Trop Crop Biotechnol, Minist Agr, Haikou 571101, Peoples R China

3.Ocean Univ China, Coll Marine Life Sci, Qingdao 266003, Peoples R China

期刊名称：CHEMISTRY OF NATURAL COMPOUNDS （ 影响因子：0.809； 五年影响因子：0.708 ）

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收录情况： SCI

摘要： The red algae Chondrophycus papillosus belongs to the genus Chondrophycus of family Rhodomelaceae, which is widely distributed in the offshore area of Guangdong and Hainan Island in China. In previous reports, only one linear diterpene, one steroid, three benzene derivatives, and sulfated xylomannans have been isolated from C. papillosus [1,2]. Recently, in the course of our search for bioactive substances from Chinese marine alga, the EtOAc crude extract of C. papillosus displayed strong in vitro activities against tumor cell lines K562, SGC-7901, and SMMC-7721. Further investigation on the chemical constituents of C. papillosus resulted in the isolation and identification of nine compounds, including three aristolane sesquiterpenes 1-3, one snyderane sesquiterpene 4, three polybrominated indoles 5-7, one linear diterpene 8, and one cholesterol derivative 9. This paper describes the isolation, structure elucidation, and bioactivity evaluation of these compounds.

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