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Phenolic compounds from the roots of valeriana officinalis var. latifolia

文献类型： 外文期刊

作者： Wang, Peng-Cheng 1 ; Ran, Xin-Hui 1 ; Luo, Huai-Rong 1 ; Ma, Qing-Yun 2 ; Liu, Yu-Qing 1 ; Zhou, Jun 1 ; Zhao, You-Xin 1 ;

作者机构： 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Peoples R China

关键词： Acetylcholinesterase inhibitory;Chemical constituents;Lignan;Valeriana officinalis var. latifolia;Valerianaceae

期刊名称：JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY （ 影响因子：1.838； 五年影响因子：1.9 ）

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收录情况： SCI

摘要： Uma nova neolignana benzofuranica, isovalerato de 9-di-hidrodesidrodiconiferila, além de 10 compostos fenólicos conhecidos, olivil, pinoresinol, 8-hidroxipinoresinol, pinorespiol, 8-hidroxi-7-epipinoresinol, ácido trans-p-hidroxifenil-propenoico, ácido cis-p-hidroxifenil-propenoico, ácido isoferúlico e isovanilina foram isolados a partir das raízes da Valeriana officinalis var. latifolia. Suas estruturas e configura??es foram elucidadas com base em métodos espectroscópicos. A atividade inibitória da acetilcolinesterase (AChE) e a atividade intensificada do fator de crescimento neural (NGF) mediada pelo crescimento de neurites em células PC12 pelos compostos isovalerato de 9-di-hidrodesidrodiconiferila e olivil foram avaliadas. A new benzofuran neolignan, dihydrodehydrodiconiferyl alcohol 9-isovalerate, along with ten known phenolic compounds, olivil, pinoresinol, 8-hydroxypinoresinol, pinorespiol, 8-hydroxy-7-epipinoresinol, trans-p-hydroxyphenyl- propenoic acid, cis-p-hydroxyphenyl-propenoic acid, ferulic acid, isoferulic acid and isovanillin were isolated from the roots of Valeriana officinalis var. latifolia. Their structures and configurations were elucidated on the basis of spectroscopic methods. The inhibitory activity for acetylcholinesterase (AChE) and enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells of dihydrodehydrodiconiferyl alcohol 9-isovaterate and olivil were evaluated.

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[1]Volvalerine A, an unprecedented N-containing sesquiterpenoid dimer derivative from Valeriana officinalis var. latifolia. Wang, Peng-Cheng,Ran, Xin-Hui,Luo, Huai-Rong,Zhou, Jun,Hu, Jiang-Miao,Ma, Qing-Yun,Zhao, You-Xing.

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