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Metabolites with Gram-negative bacteria quorum sensing inhibitory activity from the marine animal endogenic fungus Penicillium sp SCS-KFD08

文献类型： 外文期刊

作者： Kong, Fan Dong 1 ; Zhou, Li Man 1 ; Ma, Qing Yun 1 ; Huang, Sheng Zhuo 1 ; Wang, Pei 1 ; Dai, Hao Fu 1 ; Zhao, You Xin 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Peoples R China

关键词： Marine fungus;Metabolites;Penicillium sp.;Quorum sensing inhibitory activity

期刊名称：ARCHIVES OF PHARMACAL RESEARCH （ 影响因子：4.946； 五年影响因子：3.483 ）

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收录情况： SCI

摘要： Three new compounds named penicitor A, aculene E and penicitor B, as well as four known compounds, were isolated from the fermentation broth of Penicillium sp. SCS-KFD08 associated with a marine animal Sipunculus nudus from the Haikou bay of China. Their planar structures and absolute configurations were unambiguously elucidated by spectroscopic data, Mosher's method, CD spectrum analysis along with quantum ECD calculation. Among them, compounds 2-7 showed quorum sensing inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations.

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