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Secondary metabolites of the lichen-associated fungus Apiospora montagnei

文献类型： 外文期刊

作者： Wang, Hao 1 ; Umeokoli, Blessing O. 1 ; Eze, Peter 1 ; Heering, Christian 4 ; Janiak, Christoph 4 ; Mueller, Werner 1 ;

作者机构： 1.Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, Univ Str 1, D-40225 Dusseldorf, Germany

2.Nnamdi Azikiwe Univ, Dept Pharmaceut & Med Chem, Awka, Nigeria

3.Nnamdi Azikiwe Univ, Dept Pharmaceut Microbiol & Biotechnol, Awka, Nigeria

4.Heinrich Heine Univ Dusseldorf, Inst Inorgan & Struct Chem, Univ Str 1, D-40225 Dusseldorf, Germany

5.Johannes Gutenberg Univ Mainz, Univ Med, Inst Physiol Chem, Duesbergweg 6, D-55128 Mainz, Germany

6.King Saud Univ, Fac Pharm, Dept Pharmacogno

关键词： Apiospora montagnei;Cytotoxicity;X-ray diffraction

期刊名称：TETRAHEDRON LETTERS （ 影响因子：2.415； 五年影响因子：2.036 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The endolichenic fungus Apiospora montagnei isolated from the lichen Cladonia sp. was cultured on solid rice medium, yielding the new diterpenoid libertellenone L (1), the new pyridine alkaloid, 23-0-acetyl-Nhydroxyapiosporamide (2) and the new xanthone derivative 8-hydroxy-3-hydroxymethyl-9-oxo-9Hxanthene-1-carboxylic acid methyl ether (3) together with 19 known compounds (4-22). The structures of the new compounds were elucidated by 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of the new 6,7-seco-libertellenone derivative 1 was determined by single-crystal X-ray diffraction. Four additional known compounds 23-26 were isolated when NaCI or NH4CI were added to solid rice medium. Compounds 7-9, 18 and 26 exhibited significant cytotoxicity against the L5178 murine lymphoma cell line with IC50 values of 2.6, 0.2, 2.1, 2.7 and 1.7 mu M, respectively. (C) 2017 Elsevier Ltd. All rights reserved.

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