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Neoantimycins A and B, Two Unusual Benzamido Nine-Membered Dilactones from Marine-Derived Streptomyces antibioticus H12-15

文献类型： 外文期刊

作者： Hu, Chen 1 ; Zhou, Shi-Wen 1 ; Chen, Fang 1 ; Zheng, Xin-Heng 1 ; Shen, Hui-Fang 2 ; Lin, Bi-Run 2 ; Zhou, Guang-Xiong 1 ;

作者机构： 1.Jinan Univ, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China

2.Guangdong Acad Agr Sci, Inst Plant Protect, Guangzhou 510632, Guangdong, Peoples R China

关键词： Streptomyces antibioticus;secondary metabolite;strain identification;neoantimycins A and B;ECD calculations;cytotoxicity;antifungal activity

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

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收录情况： SCI

摘要： An actinomycete strain (H12-15) isolated from a sea sediment in a mangrove district was identified as Streptomyces antibioticus on the basis of 16S rDNA gene sequence analysis as well as the investigation of its morphological, physiological, and biochemical characteristics. Two novel benzamido nonacyclic dilactones, namely neoantimycins A (1) and B (2), together with the known antimycins A(1ab) (3a, b), A(2a) (4), and A(9) (5), were isolated from the culture broth of this strain. Compounds 1 and 2 are the first natural modified ATNs with an unusual benzamide unit. The structures of these new compounds, including their absolute configuration, were established on the basis of HRMS, NMR spectroscopic data, and quantum chemical ECD calculations. Their cytotoxicities against human breast adenocarcinoma cell line MCF-7, the human glioblastoma cell line SF-268, and the human lung cancer cell line NCI-H460 were also tested. All compounds exhibited mild cytotoxic activity. However, Compounds 1 and 2 showed no activity against C. albicans at the test concentration of 1 mg/mL via paper disc diffusion, while the known antimycins showed obvious antifungal activity.

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