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Retinoid protects rats against neutrophil-induced oxidative stress in acute experimental mastitis

文献类型： 外文期刊

作者： Gu, Beibei 1 ; Zhu, Yumin 2 ; Zhu, Wei 1 ; Miao, Jinfeng 1 ; Deng, Yu'E 1 ; Zou, Sixiang 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China

2.Shanghai Acad Agr Sci, Inst Anim Sci & Vet Med, Shanghai 201106, Peoples R China

关键词： Retinoid;PMN;ROS;Mastitis;Rat

期刊名称：INTERNATIONAL IMMUNOPHARMACOLOGY （ 影响因子：4.932； 五年影响因子：4.624 ）

ISSN： 1567-5769

年卷期： 2009 年 9 卷 2 期

页码：

收录情况： SCI

摘要： Activated polymorphonuclear neutrophilic leukocytes (PMN) are able to produce large quantities of bactericidal molecules such as reactive oxygen species (ROS) that are associated with tissue damage in models of inflammatory mastitis. In this study, the putative protective effect of retinoid was evaluated in a lipopolysaccharide (LPS) induced mastitis model in rats, Commencing at 10 d of gestation, retinoid (dissolved in olive oil) or an equal volume of olive oil were administered daily by gavage to pregnant rats until parturition. LPS or pyrogen-free physiological saline were infused into the mammary gland 72 h after parturition. At pre-infusion (defined as 0 h) and at 2, 4. 8,16 and 24 h post-infusion, six rats from each group were euthanized. Retinoid administration decreased PMN accumulation in mammary alveoli, significantly decreased the level of TNF-alpha in mammary tissues and IL-8 in serum at the different time points. ROS release was significantly increased after LPS infusion and was reduced by retinoid at 16 h PI. Retinoid reduced N-acetyl-beta-D-glucosaminidase (NAGase) activity in both serum and mammary tissue at 8 h Pl. Intercellular adhesion molecule 1 (ICAM-1) mRNA expression reached its peak value earlier in retinoid treated rats than in the control group. Overall, the results suggest that activated PMN play an important role in the pathogenesis of acute mastitis and retinoid administration may be an effective tool for protecting mammary tissue against PMN-induced oxidative stress during LPS-induced acute mastitis. (C) 2008 Elsevier B.V. All rights reserved.

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[1]Protective effect of retinoid against endotoxin-induced mastitis in rats. Gu, B. -B.,Miao, J. -F.,Deng, Y. -E.,Zou, S. -X.,Zhu, Y. -M.. 2009

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[4]Protective effect of CpG-DNA against mastitis induced by Escherichia coli infection in a rat model. Zhu, Yumin,Fan, Hongjie,Miao, Jinfeng,Zou, Sixiang,Zhu, Yumin. 2008

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